36151-44-7

Basic information

• Product Name: 4-(2-OXO-PYRROLIDIN-1-YL)-BENZOIC ACID
• Synonyms: benzoic acid, 4-(2-oxo-1-pyrrolidinyl)-;4-(2-oxopyrrolidin-1-yl)benzoic acid(SALTDATA: FREE);4-(2-ketopyrrolidin-1-yl)benzoic acid;4-(2-oxo-1-pyrrolidinyl)benzoic acid
• CAS NO: 36151-44-7
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.22
• Mol File: 36151-44-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 507.1 °C at 760 mmHg
• Flash Point: 260.5 °C
• Appearance: /
• Density: 1.341 g/cm³
• Vapor Pressure: 4.17E-11mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: 4-(2-OXO-PYRROLIDIN-1-YL)-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-OXO-PYRROLIDIN-1-YL)-BENZOIC ACID(36151-44-7)
• EPA Substance Registry System: 4-(2-OXO-PYRROLIDIN-1-YL)-BENZOIC ACID(36151-44-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 36151-44-7(Hazardous Substances Data)

Usage

General Description

4-(2-Oxo-pyrrolidin-1-yl)-benzoic acid is a chemical compound that belongs to the class of benzoic acid derivatives. It is a carboxylic acid with the molecular formula C13H11NO3 and a molecular weight of 225.23 g/mol. 4-(2-OXO-PYRROLIDIN-1-YL)-BENZOIC ACID is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and medications. It has also been studied for its potential biological activities, including anti-inflammatory and analgesic properties. Additionally, 4-(2-oxo-pyrrolidin-1-yl)-benzoic acid has been investigated for its potential use in the development of new materials and chemical processes.

InChI:InChI=1/C11H11NO3/c13-10-2-1-7-12(10)9-5-3-8(4-6-9)11(14)15/h3-6H,1-2,7H2,(H,14,15)

Upstream product

• 619-42-1 4-methoxycarbonylphenyl bromide 
• 139348-98-4 ethyl 4-(4-chlorobutyrylamino)benzoate 
• 150-13-0 4-amino-benzoic acid 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 619-44-3 methyl 4-iodobenzoate 
• 221381-89-1 1-(4-methoxycarbonylphenyl)pyrrolidin-2-one 
• 2969-81-5 Ethyl 4-bromobutyrate 
• 86364-65-0 ethyl <2-oxo-1-pyrrolidinyl>benzoate 

Downstream Products

• 13691-22-0 1-(4-aminophenyl)pyrrolidin-2-one 
• 4641-57-0 1-phenylpyrrolidin-2-one 
• 1003309-09-8 1-[4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)phenyl]pyrrolidin-2-one 
• 1364522-66-6 N-(4-chloro-5-(4-(3-(2-methoxyphenyl)-5-methylisoxazole-4-carbonyl)piperazin-1-yl)-2-nitrophenyl)-4-(2-oxopyrrolidin-1-yl)benzamide 
• 1232028-29-3 N-{2-[4-(2-chloro-5-fluoro-benzoyl)-piperazin-1-yl]-2-oxo-ethyl}-4-(2-oxo-pyrrolidin-1-yl)-benzamide 
• 1188373-76-3 4-(2-oxo-pyrrolidin-1-yl)-N-{2-oxo-2-[4-(3-trifluoromethyl-phenoxy)-piperidin-1-yl]-ethyl}-benzamide 
• 221381-89-1 1-(4-methoxycarbonylphenyl)pyrrolidin-2-one 
• 86364-65-0 ethyl <2-oxo-1-pyrrolidinyl>benzoate 
• 221381-92-6 1-<4-methoxycarbonyl-2-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl>pyrrolidin-2-one 
• 234110-57-7 1-{2-{[(Amino)(imino)methyl]amino}-4-carboxyphenyl}pyrrolidin-2-one 
• 221382-11-2 1-<4-methoxycarbonyl-2-(3-pentylamino)phenyl>pyrrolidin-2-one 

Relevant articles and documents

Ring size changes in the development of class I HDAC inhibitors

Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7–20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectively over other isoforms and many inhibit DLD1 and HCT116 cells more effectively than a parent compound. Compounds 8 and 16 inhibit HCT116 cells by activation of the apoptosis pathway.

3,4-dibenzamido benzamide derivative, preparation method and application thereof

The invention discloses a 3,4-dibenzamido benzamide derivative (I), wherein R1, R2 and R3 are respectively and individually hydrogen, fluorine, chlorine, bromine, hydroxyl groups, alkoxy groups, amino groups or substituted amino groups. The alkoxy groups

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE

The present invention relates to piperidine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.