36157-42-3

Basic information

• Product Name: 5-CHLOROTHIOPHENE-3-CARBOXYLIC ACID
• Synonyms: AKOS 92001;5-CHLOROTHIOPHENE-3-CARBOXYLIC ACID;3-Thiophenecarboxylic acid, 5-chloro-
• CAS NO: 36157-42-3
• Molecular Formula: C₅H₃ClO₂S
• Molecular Weight: 162.59
• Mol File: 36157-42-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 156-157 °C(Solv: water (7732-18-5))
• Boiling Point: 287 °C at 760 mmHg
• Flash Point: 127.4 °C
• Appearance: /
• Density: 1.573 g/cm³
• Vapor Pressure: 0.00119mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.82±0.10(Predicted)
• CAS DataBase Reference: 5-CHLOROTHIOPHENE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLOROTHIOPHENE-3-CARBOXYLIC ACID(36157-42-3)
• EPA Substance Registry System: 5-CHLOROTHIOPHENE-3-CARBOXYLIC ACID(36157-42-3)

Safety Data

• Hazardous Substances Data: 36157-42-3(Hazardous Substances Data)

Usage

General Description

5-Chlorothiophene-3-carboxylic acid is a chemical compound with the molecular formula C6H3ClO2S. It is a derivatized form of thiophene, a five-membered aromatic ring containing four carbon atoms and one sulfur atom. The presence of a carboxylic acid group and a chlorine atom makes this compound useful in various organic synthesis reactions and pharmaceutical applications. It is a versatile building block in the preparation of various pharmaceuticals, agrochemicals, and organic materials. 5-Chlorothiophene-3-carboxylic acid has shown potential as a precursor in the synthesis of various biologically active compounds and as a key intermediate in the production of pharmaceutical products. It is also used in research and development activities in the pharmaceutical and agrochemical industries.

InChI:InChI=1/C5H3ClO2S/c6-4-1-3(2-9-4)5(7)8/h1-2H,(H,7,8)

Upstream product

• 88-13-1 3-Thiophene carboxylic acid 
• 58119-67-8 1-(5-Chlor-3-thienyl)-ethanon 
• 36155-85-8 2-chloro-4-thiophenecarboxaldehyde 
• 36157-40-1 3-acetyl-2,5-dichlorothiophene 

Downstream Products

• 1351753-37-1 C₁₄H₁₁BrClN₃OS 
• 1351753-35-9 C₁₂H₆BrClO₂S 
• 113471-08-2 5-chloro-thiophene-3-carbonyl chloride 
• 73919-87-6 (5-chlorothiophen-3-yl)methanol 
• 71637-34-8 3-hydroxymethyl-thiophene 
• 36157-41-2 2,5-dichlorothiophene-3-carboxylic acid 

Relevant articles and documents

5-chloro-3-thiophenecarboxylic acid preparation method

The present invention discloses a 5-chloro-3-thiophenecarboxylic acid preparation method comprising the following steps: (1) adding 3-thiophenecarboxylic acid and an organic solvent into a reaction vessel, reducing the temperature to 0 DEG C to -30 DEG C, adding dropwise sulfuryl chloride into the reaction vessel, and after the addition is complete, heating slowly to 0 DEG C-20 DEG C for reaction for 1 to 3 hours; (2) after completion of the reaction, pouring the reaction solution into ice water, layering the reaction solution, separating an organic layer, drying the organic layer, filtering and concentrating to obtain a crude 5-chloro-3-thiophenecarboxylic acid product; (3) using methyl tert-butyl ether for recrystallizing the crude 5-chloro-3-thiophenecarboxylic acid product obtained in the step (2), filtering to obtain a crystal solid, and drying the crystal solid to obtain a pure 5-chloro-3-thiophenecarboxylic acid product. The novel 5-chloro-3-thiophenecarboxylic acid preparation method is provided, and a 5-chloro-3-thiophenecarboxylic acid product with a purity of 97% can be obtained.

Novel thienopyrrole glycogen phosphorylase inhibitors: Synthesis, in vitro SAR and crystallographic studies

Two series of novel thienopyrrole inhibitors of recombinant human liver glycogen phosphorylase a (GPa) which are effective in reducing glucose output from rat hepatocytes are described. Representative compounds have been shown to bind at the dimer interface site of the rabbit muscle enzyme by X-ray crystallography.

Phosphorylamides, their preparation and use

A phosphorylamide derivative represented by the general formula (I): STR1 wherein R represents an amino group that may be substituted, or a salt thereof, possesses potent antibacterial activity against Helicobacter bacterium, especially Helicobacter pylori, and is useful for prevention or treatment of digestive diseases caused by Helicobacter bacterium, solely or in combination with an antacid or an acid secretion inhibitor.