36168-42-0Relevant articles and documents
Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors
Therrien, Eric,Larouche, Guillaume,Nguyen, Natalie,Rahil, Jubrail,Lemieux, Anne-Marie,Li, Zuomei,Fournel, Marielle,Yan, Theresa P.,Landry, Anne-Julie,Lefebvre, Sylvain,Wang, James J.,MacBeth, Kyle,Heise, Carla,Nguyen, Aaron,Besterman, Jeffrey M.,Déziel, Robert,Wahhab, Amal
, p. 2514 - 2518 (2015/06/02)
Abstract A series of bicyclic pyrazole carboxamides was synthesized and tested for inhibitory activity against the class III deacetylase sirtuin enzymes. Moderate to low micromolar inhibitory activities were obtained against SIRT1 and SIRT2. These bicycli