36190-95-1 Usage
Description
3''-METHOXYOROBOL, also known as 3''-Methoxy-4'',5,7-trihydroxyisoflavone, is a derivative of Genistein (G350000). It is a compound that exhibits specific inhibitory activity against tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 2.6uM). It also inhibits other protein kinases through competitive inhibition of ATP, tumor cell proliferation, and induces tumor cell differentiation. Additionally, it produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells, while preventing anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein, the parent compound of 3''-METHOXYOROBOL, also inhibits topoisomerase II activity in vitro and the action of GABA on recombinant GABAA receptors 2.
Uses
Used in Pharmaceutical Industry:
3''-METHOXYOROBOL is used as a pharmaceutical agent for its inhibitory effects on various protein kinases and its ability to induce tumor cell differentiation and apoptosis. Its specific activity against tyrosine kinases, including the epidermal growth factor receptor kinase, makes it a promising candidate for the development of targeted cancer therapies.
Used in Cancer Research:
3''-METHOXYOROBOL is used as a research compound for studying the mechanisms of tumor cell proliferation, cell-cycle arrest, and apoptosis. Its ability to inhibit multiple protein kinases and topoisomerase II activity makes it a valuable tool in understanding the complex signaling pathways involved in cancer development and progression.
Used in Drug Development:
3''-METHOXYOROBOL is used as a lead compound in the development of new drugs targeting cancer cells. Its multifaceted inhibitory activities against various protein kinases and its effects on tumor cell differentiation and apoptosis make it a promising starting point for the design of novel anticancer drugs.
Used in Neuropharmacology:
3''-METHOXYOROBOL is used as a research tool in neuropharmacology to study the action of GABA on recombinant GABAA receptors 2. Its ability to inhibit this action provides insights into the modulation of GABAergic signaling, which is important for understanding the mechanisms underlying various neurological disorders and the development of potential therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 36190-95-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,1,9 and 0 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 36190-95:
(7*3)+(6*6)+(5*1)+(4*9)+(3*0)+(2*9)+(1*5)=121
121 % 10 = 1
So 36190-95-1 is a valid CAS Registry Number.
36190-95-1Relevant articles and documents
Microbial hydroxylation and methylation of genistein by Streptomycetes
Hosny, Mohammed,Rosazza, John P. N.
, p. 1609 - 1612 (1999)
Streptomyces griseus (ATCC 10137) and Streptomyces catenulae (ATCC 23893) were used to convert genistein-5,7,4'- trihydroxyisoflavone (1)-a major isoflavone found in soybeans, into five metabolites, four of which were previously unknown. These were 5,7,3',4'-tetrahydroxy-8-methylisoflavone (3), 5,7,3',4'-tetrahydroxy-8-methylisoflavanone (4), 5,7,4'- trihydroxy-3'-methoxyisoflavone (5), 5,7,8,3',4'-pentahy- droxyisoflavone (7), and the known compound, 5,7-dihydroxy-3',4'- dimethoxyisoflavone (6). Identities of these metabolites were established by HRFABMS and 1D and 2D NMR correlation spectroscopy.
A Versatile Microbial System for Biosynthesis of Novel Polyphenols with Altered Estrogen Receptor Binding Activity
Chemler, Joseph A.,Lim, Chin Giaw,Daiss, John L.,Koffas, Mattheos A.G.
experimental part, p. 392 - 401 (2011/06/28)
Isoflavonoids possess enormous potential for human health with potential impact on heart disease and cancer, and some display striking affinities for steroid receptors. Synthesized primarily by legumes, isoflavonoids are present in low and variable abundance within complex mixtures, complicating efforts to assess their clinical potential. To satisfy the need for controlled, efficient, and flexible biosynthesis of isoflavonoids, a three-enzyme system has been constructed in yeast that can convert natural and synthetic flavanones into their corresponding isoflavones in practical quantities. Based on the determination of the substrate requirements of isoflavone synthase, a series of natural and nonnatural isoflavones were prepared and their binding affinities for the human estrogen receptors (ERα and ERβ) were determined. Structure activity relationships are suggested based on changes to binding affinities related to small variations on the isoflavone structure.
