3622-84-2Relevant articles and documents
Chromoselective Synthesis of Sulfonyl Chlorides and Sulfonamides with Potassium Poly(heptazine imide) Photocatalyst
Antonietti, Markus,Guldi, Dirk M.,Markushyna, Yevheniia,Savateev, Aleksandr,Schü?lbauer, Christoph M.,Ullrich, Tobias
supporting information, p. 20543 - 20550 (2021/08/12)
Among external stimuli used to promote a chemical reaction, photocatalysis possesses a unique one—light. Photons are traceless reagents that provide an exclusive opportunity to alter chemoselectivity of the photocatalytic reaction varying the color of incident light. This strategy may be implemented by using a sensitizer capable to activate a specific reaction pathway depending on the excitation light. Herein, we use potassium poly(heptazine imide) (K-PHI), a type of carbon nitride, to generate selectively three different products from S-arylthioacetates simply varying the excitation light and otherwise identical conditions. Namely, arylchlorides are produced under UV/purple, sulfonyl chlorides with blue/white, and diaryldisulfides at green to red light. A combination of the negatively charged polyanion, highly positive potential of the valence band, presence of intraband states, ability to sensitize singlet oxygen, and multi-electron transfer is shown to enable this chromoselective conversion of thioacetates.
Using Small Molecules to Enhance P450 OleT Enzyme Activity in Situ
Zhang, Libo,Ma, Dumei,Yin, Yingwu,Wang, Qian
supporting information, p. 8940 - 8945 (2021/05/28)
Cytochrome P450 OleT is a fatty acid decarboxylase that catalyzes the production of olefins with biofuel and synthetic applications. However, the relatively sluggish catalytic efficiency of the enzyme limits its applications. Here, we report the application of a novel class of benzene containing small molecules to improve the OleT activity. The UV-Vis spectroscopy study and molecular docking results confirmed the high proximity of the small molecules to the heme group of OleT. Up to 6-fold increase of product yield has been achieved in the small molecule-modulated enzymatic reactions. Our work thus sheds the light to the application of small molecules to increase the OleT catalytic efficiency, which could be potentially used for future olefin productions.
Solid-phase synthesis method of N-butylbenzenesulfonamide
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Paragraph 0021-0035, (2020/04/17)
The invention discloses a solid-phase synthesis method of N-butylbenzenesulfonamide, which comprises the following steps: (1) feeding reaction, namely, carrying out a solvent-free solid-phase reactionon benzenesulfonyl chloride, an n-butylamine raw material and an inorganic alkaline compound; (2) suction filtration, namely, separating and washing the reacted solid by using an organic solvent, andcombining organic phases; and (3) distillation and purification, namely, carrying out reduced pressure distillation and purification on the combined organic phase under vacuum, and collecting 150-160DEG C/0.5mmHg of distillate to obtain the N-butylbenzenesulfonamide. Benzenesulfonyl chloride, the n-butylamine raw material and the inorganic alkaline compound are subjected to a solvent-free solid-phase reaction to synthesize N-butylbenzenesulfonamide, the method has the advantages of simple process, mild reaction conditions, high synthesis rate, safety and environmental protection, and the obtained N-butylbenzenesulfonamide has the advantages of high yield, high purity and good quality and has a wide market prospect.