36236-67-6

Basic information

• Product Name: 1-[(4-chlorophenyl)benzyl]-4-[(m-tolyl)methyl]piperazine hydrochloride
• Synonyms: 1-[(4-chlorophenyl)benzyl]-4-[(m-tolyl)methyl]piperazine hydrochloride;1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine/hydrochloride,(1:x);1-(p-Chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine hydrochloride;Einecs 252-932-4;Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-, hydrochloride
• CAS NO: 36236-67-6
• Molecular Formula: C₂₅H₂₇ClN₂*2ClH
• Molecular Weight: 427.40922
• EINECS: 252-932-4
• Mol File: 36236-67-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 577.93°C (rough estimate)
• Flash Point: 253.3°C
• Appearance: /
• Density: 1.0753 (rough estimate)
• Refractive Index: 1.6300 (estimate)
• CAS DataBase Reference: 1-[(4-chlorophenyl)benzyl]-4-[(m-tolyl)methyl]piperazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-chlorophenyl)benzyl]-4-[(m-tolyl)methyl]piperazine hydrochloride(36236-67-6)
• EPA Substance Registry System: 1-[(4-chlorophenyl)benzyl]-4-[(m-tolyl)methyl]piperazine hydrochloride(36236-67-6)

Safety Data

• Hazardous Substances Data: 36236-67-6(Hazardous Substances Data)

Usage

Chemical Properties

White or yellowish powder or crystals; slight odor. Insoluble in water and ether; very soluble in chloroform, pyridine, and acid-alcohol-water mixture; slightly soluble in dilute acids and alcohol.

Uses

Medicine (antihistamine).

InChI:InChI=1/C25H27ClN2.ClH/c1-20-5-4-6-21(17-20)18-27-13-15-28(16-14-27)19-23-7-2-3-8-25(23)22-9-11-24(26)12-10-22;/h2-12,17H,13-16,18-19H2,1H3;1H

Upstream product

• 620-19-9 1-chloromethyl-3-methyl-benzene 
• 303-26-4 N-(4-chlorobenzhydryl)piperazine 

Downstream Products

• 114624-70-3 Meclozin-N,N'-dioxid 
• 163837-33-0 (R)-1-((4-chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine dihydrochloride 
• 163837-33-0 (S)-1-((4-chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine dihydrochloride 
• 163837-49-8 C₂₅H₂₇ClN₂ 
• 163837-49-8 C₂₅H₂₇ClN₂ 
• 163837-33-0 C₂₅H₂₇ClN₂*ClH 

Relevant articles and documents

NOVEL WATER BASED PROCESS FOR THE PREPARATION OF SUBSTITUTED DIPHENYLMETHYL PIPERAZINES

The present invention relates to a novel water based process for the preparation of substituted diphenylmethyl piperazines of Formula I and pharmaceutically acceptable salts wherein X1 and X2 represent independently a hydrogen, a halogen, a straight or branched chain lower alkyl, alkoxy or a hydroxyl radical and R is selected from groups such as acyl, alkyl, alkenyl, aralalkyl, aralalkenyl aralkyl, and aralalkenyl or aralkenyl hydroxyalkyl, aryloxyalkyl, alkoxyalkyl, aminoalkyl or its derivative comprising, reacting a compound of Formula II, with a compound of formula R—X where R is as defined above and X is suitable leaving group which includes halides, but not limiting use of other leaving groups such as tosylate, mesylate and activated acid groups such as acyl halide, anhydrides, mixed anhydrides etc. using water as a solvent, in presence of a catalyst and a base, at 25-100° C.;