362529-31-5

Basic information

• Product Name: N-(3-CHLOROMETHYL-PHENYL)-METHANESULFONAMIDE
• Synonyms: N-(3-CHLOROMETHYL-PHENYL)-METHANESULFONAMIDE;Methanesulfonamide, N-[3-(chloromethyl)phenyl]-
• CAS NO: 362529-31-5
• Molecular Formula: C₈H₁₀ClNO₂S
• Molecular Weight: 219.69
• Mol File: 362529-31-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 349.2±44.0 °C(Predicted)
• Appearance: /
• Density: 1.393±0.06 g/cm3(Predicted)
• PKA: 8.31±0.10(Predicted)
• CAS DataBase Reference: N-(3-CHLOROMETHYL-PHENYL)-METHANESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-CHLOROMETHYL-PHENYL)-METHANESULFONAMIDE(362529-31-5)
• EPA Substance Registry System: N-(3-CHLOROMETHYL-PHENYL)-METHANESULFONAMIDE(362529-31-5)

Safety Data

• Hazardous Substances Data: 362529-31-5(Hazardous Substances Data)

Usage

General Description

N-(3-chloromethyl-phenyl)-methanesulfonamide is a chemical compound with the molecular formula C8H9ClNO2S. It is an organic sulfonyl compound that contains a chlorine atom and a phenyl group attached to a methanesulfonamide moiety. N-(3-CHLOROMETHYL-PHENYL)-METHANESULFONAMIDE is used in the production of pharmaceuticals and agrochemicals as a building block for the synthesis of various biologically active compounds. It has been studied for its potential use as an antineoplastic agent and has shown promise in inhibiting the growth of cancer cells in vitro. Additionally, it has been investigated for its antimicrobial and antifungal properties. Overall, N-(3-chloromethyl-phenyl)-methanesulfonamide has potential applications in the fields of medicine and agriculture due to its diverse chemical reactivity and biological activity.

Upstream product

• 1877-77-6 3-aminobenzenemethanol 
• 145883-50-7 3-(chloromethyl)aniline hydrochloride 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 1353656-53-7 C₂₁H₁₇N₅O₂S₂ 
• 114100-09-3 N-(3-aminomethylphenyl)-methanesulfonamide 
• 565448-32-0 N-[3-(azidomethyl)phenyl]methanesulfonamide 

Relevant articles and documents

SUBSTITUTED DICYANOPYRIDINES AND USE THEREOF

The present application relates to novel substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders.

N-(3-acyloxy-2-benzylpropyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues: Novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor

Isosteric replacement of the phenolic hydroxyl group in potent vanilloid receptor (VR1) agonists with the alkylsulfonamido group provides a series of compounds which are effective antagonists to the action of the capsaicin on rat VR1 heterologously expressed in Chinese hamster ovary (CHO) cells. In particular, compound 61, N-[2-(3,4-dimethylbenzyl)-3-pivaloyloxypropyl]-N′-[3-fluoro-4- (methylsulfonylamino)benzyl]thiourea was a full antagonist against capsaicin, displayed a Ki value of 7.8 nM (compared to 520 nM for capsazepine and 4 nM for 5-iodoRTX), and showed excellent analgesic activity in mice. Structure-activity analysis of the influence of modifications in the A- and C-regions of 4-methylsulfonamide ligands on VR1 agonism/antagonism indicated that 3-fluoro substitution in the A-region and a 4-tert-butylbenzyl moiety in the C-region favored antagonism, whereas a 3-methoxy group in the A-region and 3-acyloxy2-benzylpropyl moieties in the C-region favored agonism.