362640-59-3

Basic information

• Product Name: 1-phenyl-3-(trifluoroMethyl)-1H-pyrazole-5-carboxylic acid
• Synonyms: 1-phenyl-3-(trifluoroMethyl)-1H-pyrazole-5-carboxylic acid
• CAS NO: 362640-59-3
• Molecular Formula: C₁₁H₇F₃N₂O₂
• Molecular Weight: 256.1806896
• Mol File: 362640-59-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 371.4±42.0 °C(Predicted)
• Appearance: /
• Density: 1.44±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.44±0.10(Predicted)
• CAS DataBase Reference: 1-phenyl-3-(trifluoroMethyl)-1H-pyrazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-3-(trifluoroMethyl)-1H-pyrazole-5-carboxylic acid(362640-59-3)
• EPA Substance Registry System: 1-phenyl-3-(trifluoroMethyl)-1H-pyrazole-5-carboxylic acid(362640-59-3)

Safety Data

• Hazardous Substances Data: 362640-59-3(Hazardous Substances Data)

Usage

General Description

The chemical 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid is a compound with the molecular formula C11H8F3N3O2. It is a derivative of pyrazole and contains a phenyl group and a trifluoromethyl group. 1-phenyl-3-(trifluoroMethyl)-1H-pyrazole-5-carboxylic acid has potential applications in the pharmaceutical industry, particularly as a building block for the synthesis of more complex organic compounds. Its structure and properties make it suitable for use in drug development, where it may exhibit biological activity and therapeutic potential. Research and development in the field of medicinal chemistry may explore the use of this compound for various pharmacological purposes.

Upstream product

• 111079-04-0 5-methyl-1-phenyl-3-(trifluoromethyl)-1H-pyrazole 
• 515845-27-9 3-trifluoromethyl-5-(fur-2-yl)-1-phenyl-1H-pyrazole 
• 326-90-9 4,4,4-trifluoro-1-(2-furanyl)-1,3-butanedione 
• 367-57-7 1,1,1-Trifluoro-2,4-pentanedione 
• 100-63-0 phenylhydrazine 
• 81963-53-3 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid methyl ester 

Downstream Products

• 362640-60-6 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride 
• 1288340-47-5 methyl 1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylate 
• 1288340-48-6 1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carbaldehyde 
• 1288340-49-7 5-(fluoromethyl)-1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole 
• 1288340-50-0 5-(difluoromethyl)-1-(4-nitrophenyl)-3-(trifluoromethyl)-1H-pyrazole 
• 1288340-58-8 4-[5-(fluoromethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]aniline 
• 1288340-59-9 4-[5-(difluoromethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]aniline 
• 81963-53-3 1-phenyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid methyl ester 

Relevant articles and documents

New synthetic access to 3-fluoroalkyl-5-pyrazolecarboxylates and carboxylic acids

A novel process for preparing 3-fluoroalkyl-5-pyrazolecarboxylates and carboxylic acids is hereby presented. Easily accesible α-fluorinated ketimines were condensed with oxalyl monochloride derivatives, and the obtained vinamides underwent acid-catalyzed cyclization with substituted hydrazines. This highly efficient protocol can also be used for non-fluorinated C-3 and C-5 substituents.

Synthesis, nematicidal activity and docking study of novel chromone derivatives containing substituted pyrazole

A series of chromone derivatives containing substituted pyrazole were designed and synthesized. Preliminary bioassays showed that most of the synthesized compounds exhibited good nematicidal activity in vivo against Meloidogyne incognita at 10 mg/L. Among the tested compounds, A10 and A11 exhibited 100% inhibition rates. In addition, the molecular docking results indicated that both compound A10 and A11 interacts with amino acid residue Tyr121, Trp279, Tyr70, Trp84 and Phe330 of AChE via hydrogen bond and π–π stacking. This investigation suggested that the chromone containing substituted pyrazole scaffold could be further optimized to explore novel, high-bioactivity nematicidal leads.

Method of controlling particular insect pests by applying anthranilamide compounds

This invention pertains to a method for controlling lepidopteran, homopteran, hemipteran, thysanopteran and coleopteran insect pests comprising contacting the insects or their environment with an arthropodicidally effective amount of a compound of Formula I, its N-oxide or an agriculturally suitable salt thereof wherein A and B and R1 through R8 are as defined in the disclosure. This invention further relates to a benzoxazinone compound of Formula 10 wherein R4 through R8 are as defined in the disclosure, useful for preparation of a compound of Formula I.