36342-10-6

Basic information

• Product Name: (2E)-4-[(4-nitrophenyl)amino]-4-oxobut-2-enoic acid
• Synonyms: (2E)-4-[(4-Nitrophenyl)amino]-4-oxobut-2-enoic acid; 2-butenoic acid, 4-[(4-nitrophenyl)amino]-4-oxo-, (2E)-
• CAS NO: 36342-10-6
• Molecular Formula: C₁₀H₈N₂O₅
• Molecular Weight: 236.1809
• Mol File: 36342-10-6.mol
• Article Data: 40

Chemical Properties

• Boiling Point: 536.4°C at 760 mmHg
• Flash Point: 278.2°C
• Density: 1.517g/cm³
• Vapor Pressure: 2.46E-12mmHg at 25°C
• Refractive Index: 1.667
• CAS DataBase Reference: (2E)-4-[(4-nitrophenyl)amino]-4-oxobut-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-4-[(4-nitrophenyl)amino]-4-oxobut-2-enoic acid(36342-10-6)
• EPA Substance Registry System: (2E)-4-[(4-nitrophenyl)amino]-4-oxobut-2-enoic acid(36342-10-6)

Safety Data

• Hazardous Substances Data: 36342-10-6(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2E)-4-[(4-nitrophenyl)amino]-4-oxobut-2-enoic acid" is a synthetic compound with the molecular formula C10H10N2O6. It belongs to the class of organic compounds known as nitroanilines, which are aromatic amines carrying a nitro group at the para-position. It is a yellow crystalline solid and is used in the synthesis of pharmaceuticals and other organic compounds. (2E)-4-[(4-nitrophenyl)amino]-4-oxobut-2-enoic acid has potential applications in the field of medicine and biochemistry due to its unique structure and properties. Additionally, it may also have uses in the production of dyes and colorants due to its vibrant color and chemical composition.

Upstream product

• 108-31-6 maleic anhydride 
• 100-01-6 4-nitro-aniline 
• 80818-24-2 (Z)-(2-methyl-4-(4-nitrophenylamino)-4-oxo)but-2-enoic acid 
• 785-81-9 4-nitro-N-(phenylmethylene)benzenamine 
• 627-63-4 fumaryl dichloride 

Downstream Products

• 4338-06-1 N-(4-nitrophenyl)maleimide 
• 37904-11-3 3-chloro-1-(4-nitrophenyl)pyrrolidine-2,5-dione 
• 1415110-33-6 diethyl 3-[(tert-butoxycarbonyl)(4-nitrophenyl)-carbamoyl]cyclopropane-1,2-dicarboxylate 
• 1415110-31-4 diethyl 3-[(4-nitrophenyl)carbamoyl]cyclopropane-1,2-dicarboxylate 

Relevant articles and documents

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Novel p-nitrophenyl maleanilic acid and its organometallic chelates of Cr, Mo and W carbonyls structure evaluation using different techniques and chromium chelate cytotoxicity

Novel p-nitrophenyl maleanilic acid bidentate free ligand (PNMA) was synthesized eco-friendly by solvent free reaction between 4-nitroaniline and maleic anhydride. Some novel mixed ligand organometallic chelates of formulae [M(CO)4L] (M = Cr, Mo, or W and

Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents

A series of 3,4-dihydro-2(1H)-quinolinone derivatives contained butenediamide fragment were designed and synthesized. Their inhibition potency against chitin synthase and antimicrobial activities were screened in vitro. The enzymatic assays showed that all the synthesized compounds had inhibition potency against chitin synthase at concentration of 300 μg/mL. Compound 2d displayed excellent potency with inhibition percentage (IP) value of 82.3%, while IP value of the control polyoxin B was 87.5%. Compounds 2b, 2e and 2s whose IP values were above 70% showed good inhibition potency against chitin synthase. Moreover, the IC50 value of 2b was comparable with that of polyoxin B (0.09 mM). The Ki of compound 2b was 0.12 mM and the result from Lineweaver-Burk plot showed that 2b was non-competitive inhibitor to bind chitin synthase. The antifungal experiment showed that these compounds had excellent antifungal activity against fungal strains, especially for candida albicans. The antifungal activities against C .albicans of compounds 2b, 2d, 2e and 2l were comparable with that of fluconazole and were superior to that of polyoxin B. Meanwhile, the other compounds against C. albicans showed better antifungal activity (MIC 2 μg/mL) than polyoxin B except for compound 2n (MIC 4 μg/mL). The trial of drug combination use showed that these synthesized compounds had synergistic effects with fluconazole and polyoxin B. It indicated that these compounds were not competing with polyoxin B to bind with chitin synthase, which was also consistence with the result of enzymatic assays. The antibacterial experiment showed that these compounds had no activity against selected strains including three Gram-positive and three Gram-negative bacteria. These results showed that the designed compounds were chitin synthase inhibitors and had selective antifungal activity.