36392-74-2 Usage
Description
2-azaspiro[4.5]decane hydrochloride is a heterocyclic compound characterized by its unique spiro skeleton, which is prevalent in many biologically active molecules. It serves as a crucial pharmaceutical intermediate in the synthesis of various medications, particularly those targeting the central nervous system.
Uses
Used in Pharmaceutical Industry:
2-azaspiro[4.5]decane hydrochloride is used as a pharmaceutical intermediate for the synthesis of medications, primarily in the development of central nervous system drugs. Its unique spiro skeleton contributes to the biological activity of the resulting compounds, making it a valuable component in drug discovery and design.
Used in Research and Development:
In the field of research and development, 2-azaspiro[4.5]decane hydrochloride is utilized for the creation of novel drugs aimed at treating neurological disorders and psychiatric conditions. Its presence in the molecular structure of these drugs can potentially enhance their therapeutic effects and improve patient outcomes.
Used for Improved Solubility and Stability:
The hydrochloride salt form of 2-azaspiro[4.5]decane is favored for its enhanced solubility and stability, which are essential properties for pharmaceutical applications. This form ensures that the compound remains effective and consistent throughout the drug development process, ultimately leading to safer and more reliable medications.
Check Digit Verification of cas no
The CAS Registry Mumber 36392-74-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,3,9 and 2 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 36392-74:
(7*3)+(6*6)+(5*3)+(4*9)+(3*2)+(2*7)+(1*4)=132
132 % 10 = 2
So 36392-74-2 is a valid CAS Registry Number.
36392-74-2Relevant articles and documents
Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus
Wang, Jun,Cady, Sarah D.,Balannik, Victoria,Pinto, Lawrence H.,DeGrado, William F.,Hong, Mei
experimental part, p. 8066 - 8076 (2009/12/03)
Amantadine has been used for decades as an inhibitor of the influenza A virus M2 protein (AM2) in the prophylaxis and treatment of influenza A infections, but its clinical use has been limited by its central nervous system (CNS) side effects as well as emerging drug-resistant strains of the virus. With the goal of searching for new classes of M2 inhibitors, a structure-activity relation study based on 2-[3-azaspiro(5,5)undecanol]-2-midazoline (BL-1743) was initiated. The first generation BL-1743 series of compounds has been synthesized and tested by two-electrode voltage-clamp (TEV) assays. The most active compound from this library, 3-azaspiro[5,5]undecane hydrochloride (9), showed an IC50 as low as0.92 ± 0.11 μM against AM2, more than an order of magnitude m ore potent than amantadine (IC50 = 16 μM). 15N and 13C solid-state NMR was employed to determine the effect of compound 9 on the structure and dynamics of the transmembrane domain of AM2 (AM2-TM) in phospholipid bilayers. Compared to amantadine, spiro-piperidine 9 (1) induces a more homogeneous conformation of the peptide,(2) reduces the dynamic disorder of the G34-I35 backbone near the water -filled central cavity of the helical bundle, and (3) influences the dynamics and magnetic environment of more residues within the transmembranehelices. These data suggest that spiro-piperidine 9 binds more extensiv ely with the AM2 channel, thus leading to stronger inhibitory potency.
