3641-08-5Relevant articles and documents
Synthesis of nucleotide analogues by a promiscuous phosphoribosyltransferase
Seism, Robert A.,Stec, Donald F.,Bachmann, Brian O.
, p. 4179 - 4182 (2007)
An Escherichia coli strain overexpressing a mutant variant of a phosphoribosyl transferase was developed as a catalyst for the efficient preparation of a range of purine nucleotide analogues. This system offers an efficient and rapid method for nucleotide analogue synthesis with 100% β-selectivity, providing analytically pure product in a single purification step.
Synthesis process of ribavirin intermediate and the intermediate
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Paragraph 0074-0076; 0080; 0086; 0089; 0090; 0093, (2020/08/12)
The invention discloses a synthesis process of a ribavirin intermediate and the intermediate. 2-hydrazinyl-2-oxoacetate is used as a raw material, and the ribavirin intermediate 1,2,4-triazole-3-formamide is obtained by condensation with orthoformate triester, ammonolysis and cyclization in sequence. According to the process, the 2-hydrazinyl-2-oxoacetate is adopted as the initial raw material, the raw material is easily available and cheap, the synthesis route is short, expensive raw materials such as hypophosphorous acid are not adopted, dangerous raw materials such as hydrogen peroxide arenot used, a diazotization reaction which is a dangerous process is not adopted, reaction condition is mild, the whole process is almost free of generation of wastewater and solid waste; and the process is green, simple to operate and high in yield.
Synthetic method of 1,2,4-triazole-3-formamide
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Page/Page column 4-6, (2018/12/05)
The invention belongs to the preparation field of synthesis of key intermediates of an antiviral drug ribavirin and discloses a method for preparing 1,2,4-triazole-3-formamide. The method comprises the steps that under the effect of alkali, aminooxamide and ethyl formimidate hydrochloride produce cyclization reaction to generate the 1,2,4-triazole-3-formamide. According to the method, raw materials are easy to obtain, a synthesis route is short, posttreatment is convenient and simple, no pollution is produced during reaction, the amount of three wastes is small, and the preparation field is suitable for industrial production.