36482-37-8

Basic information

• Product Name: 1-[(1S)-1-phenylethyl]piperidin-4-one
• Synonyms: 1-[(1S)-1-phenylethyl]-4-Piperidinone
• CAS NO: 36482-37-8
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.2802
• Mol File: 36482-37-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 310.7°C at 760 mmHg
• Flash Point: 132.5°C
• Density: 1.072g/cm³
• Vapor Pressure: 0.000591mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: 1-[(1S)-1-phenylethyl]piperidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(1S)-1-phenylethyl]piperidin-4-one(36482-37-8)
• EPA Substance Registry System: 1-[(1S)-1-phenylethyl]piperidin-4-one(36482-37-8)

Safety Data

• Hazardous Substances Data: 36482-37-8(Hazardous Substances Data)

Usage

Functional groups

Ketone, Piperidine ring, Phenethyl group

Chemical classification

Ketone derivative of piperidine

Usage

Intermediate in the synthesis of pharmaceuticals and other organic compounds

Application

Precursor in the synthesis of various psychoactive substances

Structure

Piperidine ring with a phenethyl group and a ketone functional group

Importance

Building block in organic chemistry

Potential applications

Medicinal and pharmaceutical research due to diverse chemical properties

Upstream product

• 2627-86-3 (S)-1-phenyl-ethylamine 
• 26822-37-7 N,N-dimethyl-4-oxopiperidinium iodide 
• 618-36-0 rac-methylbenzylamine 
• 1445-73-4 1-Methyl-4-piperidone 

Downstream Products

• 104829-89-2 1-(S-α-phenylethyl)-4-(2-carbomethoxypyrrolidino)-3-piperideine 
• 1239701-58-6 (S)-8-chloro-11-1-(1-(1-phenylethyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2b]pyridine 
• 1590400-91-1 (11S)-(-)-8-(1-phenylethyl)-1,4-dioxa-8-azaspiro[4.5]decane 
• 1590400-93-3 (11S,7R)-(-)-8-(1-phenylethyl)-1,4-dioxa-8-azaspiro[4.5]decane-7-carbonitrile 
• 89608-20-8 1-(S-α-phenylethyl)-4-pyrrolidino-3-piperideine 
• 104829-90-5 1,2-trimethylene-1,8-diaza-4-oxaspiro<4,5>decane 
• 89608-06-0 1-(S-α-phenylethyl)-3-(2-carbomethoxyethyl)-4-piperidone 
• 104829-87-0 1-(S-α-phenylethyl)-3-(2-cyanoethyl)-4-piperidone 
• 104829-88-1 1-(S-α-phenylethyl)-3-(2-cyanoethyl)-4-piperidone 
• 89608-07-1 1-(S-α-phenylethyl)-3-(2-cyanoethyl)piperidin-4-one 
• 478685-72-2 C₂₂H₂₄N₂O₂ 

Relevant articles and documents

(S)-(-)-α-Methylbenzylamine as chiral auxiliary in the synthesis of (+)-lortalamine

(+)-Lortalamine was synthesised using (S)-(-)-α-methylbenzylamine as a chiral auxiliary. The stereochemistry of an intermediate compound was established on the basis of X-ray crystallography, allowing unambiguous assignment of the absolute configuration.

BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS

This invention is directed to benzenesulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment of diseases or conditions associated with voltage-gated sodium channels, such as epilepsy.

Synthesis and antihistamine evaluations of novel loratadine analogues

A series of loratadine analogues containing hydroxyl group and chiral center were synthesized. The effect of the synthesized compounds on the histamine-induced contractions of guinea-pig ileum muscles was studied. In addition, the in vivo asthma-relieving effect of the analogues in the histamine induced asthmatic reaction in guinea-pigs was determined. Most of the compounds exhibited definite H1 antihistamine activity. The S-enantiomers, compounds 2, 4 and 8, are more potent than the R-enantiomers, compounds 1, 3 and 7. Compound 6 was the most active one among the eight synthesized compounds.