3652-48-0

Basic information

• Product Name: 1H-Pyrrole-3-carboxylic acid, 2-methyl-5-phenyl-, ethyl ester
• CAS NO: 3652-48-0
• Molecular Formula: C14H15NO2
• Molecular Weight: 229.279
• Mol File: 3652-48-0.mol
• Article Data: 26

Chemical Properties

• CAS DataBase Reference: 1H-Pyrrole-3-carboxylic acid, 2-methyl-5-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-carboxylic acid, 2-methyl-5-phenyl-, ethyl ester(3652-48-0)
• EPA Substance Registry System: 1H-Pyrrole-3-carboxylic acid, 2-methyl-5-phenyl-, ethyl ester(3652-48-0)

Safety Data

• Hazardous Substances Data: 3652-48-0(Hazardous Substances Data)

Usage

General Description

1H-Pyrrole-3-carboxylic acid, 2-methyl-5-phenyl-, ethyl ester is a chemical compound with the molecular formula C16H15NO2. It is an ethyl ester derivative of 2-methyl-5-phenyl-1H-pyrrole-3-carboxylic acid. 1H-Pyrrole-3-carboxylic acid, 2-methyl-5-phenyl-, ethyl ester belongs to the class of pyrrole carboxylic acid derivatives, which are known for their diverse biological activities. 1H-Pyrrole-3-carboxylic acid, 2-methyl-5-phenyl-, ethyl ester may have potential applications in pharmaceuticals and research, as it is structurally similar to other compounds with known biological activities. Its specific properties and applications would depend on further research and testing.

Upstream product

• 52313-46-9 ethyl 2-acetyl-4-oxo-4-phenylbutanoate 
• 67-56-1 methanol 
• 129612-98-2 4-Diazo-2-methyl-5-phenyl-4H-pyrrole-3-carboxylic acid ethyl ester 
• 626-34-6 ethyl aminocrotonate 
• 7654-06-0 3-phenyl-2H-azirine 
• 29113-64-2 ethyl 2-methyl-5-phenylfuran-3-carboxylate 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 2009-97-4 ethyl 2-diazo-3-oxobutanoate 
• 109681-42-7 tert-butyl-dimethyl-(1-phenyl-vinyl)-silane 
• 141-97-9 ethyl acetoacetate 
• 70-11-1 α-bromoacetophenone 
• 98-88-4 benzoyl chloride 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 
• 4636-16-2 iodoacetophenone 

Downstream Products

• 83798-51-0 ethyl 4-chloro-2-methyl-5-phenyl-1H-pyrrole-3-carboxylate 
• 3652-47-9 ethyl 1,2-dimethyl-5-phenyl-1H-pyrrole-3-carboxylate 
• 1132922-49-6 1-(4-chlorobenzyl)-2-methyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 881678-67-7 2-methyl-5-phenyl-1-(phenylsulfonyl)-1H-pyrrole-3-carbaldehyde 
• 881673-38-7 ethyl 1-[(4-fluorophenyl)sulfonyl]-2-methyl-5-phenyl-1H-pyrrole-3-carboxylate 
• 881675-08-7 ethyl 2-methyl-1-[(3-methylphenyl)sulfonyl]-5-phenyl-1H-pyrrole-3-carboxylate 
• 881675-06-5 ethyl 1-[(3-chlorophenyl)sulfonyl]-2-methyl-5-phenyl-1H-pyrrole-3-carboxylate 
• 58803-42-2 1-(5-methyl-2-phenyl-pyrrol-3-yl)-ethanone 
• 113968-05-1 ethyl 3-amino-2-hydroxy-5-methyl-2-phenyl-2H-pyrrole-4-carboxylate 
• 59133-02-7 ethyl 4-amino-2-methyl-5-phenylpyrrol-3-yl-carboxylate 
• 83798-57-6 4-Iodo-2-methyl-5-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 58803-40-0 4-bromo-2-methyl-5-phenyl-pyrrole-3-carboxylic acid ethyl ester 
• 5441-73-6 2-methyl-5-phenyl-1H-pyrrole-3-carboxylic acid 
• 859067-13-3 4-acetyl-2-methyl-5-phenyl-pyrrole-3-carboxylic acid ethyl ester 

Relevant articles and documents

Design, synthesis and biological evaluation of novel pyrrole derivatives as potential ClpP1P2 inhibitor against Mycobacterium tuberculosis

In an effort to discover novel inhibitors of M. tuberculosis Caseinolytic proteases (ClpP1P2), a combination strategy of virtual high-throughput screening and in vitro assay was employed and a new pyrrole compound, 1-(2-chloro-6-fluorobenzyl)-2, 5-dimethyl-4-((phenethylamino)methyl)-1H-pyrrole-3-carboxylate was found to display inhibitory effects against H37Ra with an MIC value of 77 μM. In order for discovery of more potent anti-tubercular agents that inhibit ClpP1P2 peptidase in M. tuberculosis, a series of pyrrole derivatives were designed and synthesized based on this hit compound. The synthesized compounds were evaluated for in vitro studies against ClpP1P2 peptidase and anti-tubercular activities were also evaluated. The most promising compounds 2-(4-bromophenyl)-N-((1-(2-chloro-6-fluorophenyl)-2, 5-dimethyl-1H- pyrrolyl)methyl)ethan-1-aminehydrochloride 7d, ethyl 4-(((4-bromophenethyl) amino) methyl)-2,5-dimethyl-1-phenyl-1H-pyrrole-3-carboxylate hydrochloride 13i, ethyl 1-(4-chlorophenyl)-4-(((2-fluorophenethyl)amino)methyl)-2-methyl-5-phenyl-1H-pyrrole-3-carboxylate hydrochloride 13n exhibited favorable anti-mycobacterial activity with MIC value at 5 μM against Mtb H37Ra, respectively.

The synthesis of pyrroles and oxazoles based on gold α-imino carbene complexes

Cationic gold complexes of α-oximimino carbenes have been identified to react with weak nucleophiles including enol ethers and nitriles. These findings allowed us to develop the highly efficient synthesis of pyrroles and oxazoles.

Copper-Catalyzed Coupling of 2-Siloxy-1-alkenes and Diazocarbonyl Compounds: Approach to Multisubstituted Furans, Pyrroles, and Thiophenes

We report herein copper(II)-catalyzed cyclization reactions of silyl enol ethers derived from methyl ketones with α-diazo-β-ketoesters or α-diazoketones to afford 2-siloxy-2,3-dihydrofuran derivatives or 2,3,5-trisubstituted furans, respectively, under mild conditions. The former cyclization products serve as versatile 1,4-diketone surrogates, allowing facile preparation of 2,3,5-trisubstituted furans, pyrroles, and thiophenes.