365242-43-9

Basic information

• Product Name: 1,2-DIHYDRO-2-TRIFLUOROMETHYL-4H-THIENO-[2,3-C]-CHROMENE-4-ONE
• Synonyms: 1,2-DIHYDRO-2-TRIFLUOROMETHYL-4H-THIENO-[2,3-C]-CHROMENE-4-ONE
• CAS NO: 365242-43-9
• Molecular Formula: C₁₂H₇F₃O₂S
• Molecular Weight: 272.24
• Mol File: 365242-43-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-DIHYDRO-2-TRIFLUOROMETHYL-4H-THIENO-[2,3-C]-CHROMENE-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DIHYDRO-2-TRIFLUOROMETHYL-4H-THIENO-[2,3-C]-CHROMENE-4-ONE(365242-43-9)
• EPA Substance Registry System: 1,2-DIHYDRO-2-TRIFLUOROMETHYL-4H-THIENO-[2,3-C]-CHROMENE-4-ONE(365242-43-9)

Safety Data

• Hazardous Substances Data: 365242-43-9(Hazardous Substances Data)

Usage

Type of Compound

Fluorinated heterocyclic compound

Potential Applications

Pharmaceutical and agrochemical industries

Structure

a. Incorporates both a thieno and chromene ring
b. Trifluoromethyl group attached to the second carbon of the chromene ring

Presence of Fluorine Atoms

Enhances stability and lipophilicity

Attractiveness

Makes it a candidate for drug design and development

Biological Activities

May exhibit various biological activities

Further Study

Potential as a drug candidate or as a precursor for the synthesis of other chemicals warrants investigation

Upstream product

• 623-51-8 ethyl 2-sulfanylacetate 
• 151668-40-5 2-trifluoromethyl-4-chromone 

Downstream Products

• 70817-40-2 3-hydrazino-6-(2-hydroxyphenyl)pyridazine 

Relevant articles and documents

Unexpected synthesis of dihydrothienocoumarin derivatives from 2-trifluoromethylchromones and ethyl mercaptoacetate

The redox reaction of 2-trifluoromethylchromones with ethyl mercaptoacetate in the presence of triethylamine results in the formation of dihydrothienocoumarin derivatives and diethyl 3,4-dithiadipate in high yields.

Unusual reaction of 2-(trifluoromethyl)-1,2-dihydro-3λ6-thieno- [2,3-c]chromen-3,3,4-triones with hydrazine as a new route to 3-hydrazinopyridazine derivatives

Oxidation of 2-(trifluoromethyl)-1,2-dihydro-4H-thieno[2,3-c]chromen-4-ones 2 with H2O2 in AcOH gives 2-(trifluoromethyl)-1,2-dihydrothieno[2,3-c]chromen-3,3,4-triones 3, which are transformed into 3-hydrazinopyridazine derivatives 4 in high yields by treatment with hydrazine hydrate in ethanol.