Welcome to LookChem.com Sign In|Join Free

CAS

  • or

365998-36-3

Post Buying Request

365998-36-3 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • : (5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4,6-dihydro-,1,1-diMethylethyl ester

    Cas No: 365998-36-3

  • No Data

  • 1 Kilogram

  • 20 Metric Ton/Month

  • Henan Allgreen Chemical Co.,Ltd
  • Contact Supplier
  • High Quality 99% 365998-36-3 (5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4,6-dihydro-

    Cas No: 365998-36-3

  • USD $ 0.1-0.1 / Gram

  • 1 Gram

  • 100 Metric Ton/Year

  • Xi'an Xszo Chem Co., Ltd.
  • Contact Supplier
  • tert-Butyl [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate

    Cas No: 365998-36-3

  • No Data

  • 1 Metric Ton

  • 1 million Metric Ton/Year

  • COLORCOM LTD.
  • Contact Supplier
  • Carbamic acid, N-[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]-, 1,1-dimethylethyl ester

    Cas No: 365998-36-3

  • USD $ 1.2-5.0 / Kiloliter

  • 5 Kiloliter

  • 3000 Metric Ton/Month

  • Chemwill Asia Co., Ltd.
  • Contact Supplier
  • 365998-36-3 (5H-Pyrrolo[3,4-d]thiazole-5-carboxylic acid,2-[[[(1R,2S,5S)-2-[[(5-chloro-1H-indol-2-yl)carbonyl]aMino]-5-[(diMethylaMino)carbonyl]cyclohexyl]aMino]carbonyl]-4,6-dihydro-,

    Cas No: 365998-36-3

  • No Data

  • 1 Kilogram

  • 10 Metric Ton/Month

  • Henan Tianfu Chemical Co., Ltd.
  • Contact Supplier

365998-36-3 Usage

Uses

tert-Butyl [(1R,2S,5S)-2-Amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate is a reagent used in the synthesis of cis-1,2-diaminocyclohexane derivative, which are factor Xa (fXa) inhibitors.

Check Digit Verification of cas no

The CAS Registry Mumber 365998-36-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,5,9,9 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 365998-36:
(8*3)+(7*6)+(6*5)+(5*9)+(4*9)+(3*8)+(2*3)+(1*6)=213
213 % 10 = 3
So 365998-36-3 is a valid CAS Registry Number.

365998-36-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate

1.2 Other means of identification

Product number -
Other names [(1R,2S,5S)-2-Amino-5-(dimethylcarbamoyl)cyclohexyl]carbamic acid tert‐butyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:365998-36-3 SDS

365998-36-3Relevant articles and documents

Method for preparing eteaban chiral amine intermediate (by machine translation)

-

, (2020/09/12)

The invention provides a safe and convenient method for preparing N - [(1R, 2S, 5S) -2 - amino -5 - [(dimethylamino) carbonyl] cyclohexyl] carbamic acid tert-butyl formate. The compound N - [(1R, 2R, 5S) -5 - [(dimethylamino) carbonyl] -2 - hydroxycyclohexyl] carbamic acid tert-butyl carbamate and the DBU azidate are then reacted to obtain N - [(1R, 2R, 5S) -5 - [(dimethylamino) carbonyl] cyclohexyl] carbamic acid tert-butyl formate in the presence of DBU to obtain the corresponding amino. N - [(1R, 2S, 5S) -2 - amino -2 -5 - [(dimethylamino) carbonyl] cyclohexyl] carbamic acid tert-butyl formate in the presence of a DBU to obtain the corresponding amino compound. N - 2S [(dimethylamino) carbonyl] cyclohexyl] carbamic acid tert-butyl formate 1R 5S -2 -5 . (by machine translation)

Development of an Efficient Manufacturing Process for a Key Intermediate in the Synthesis of Edoxaban

Michida, Makoto,Ishikawa, Hideaki,Kaneda, Takeshi,Tatekabe, Shinya,Nakamura, Yoshitaka

, p. 524 - 534 (2019/03/07)

We report the development of a novel synthetic method to access a key intermediate in the synthesis of edoxaban. The main features of the new synthetic method are an improvement in the approach for the synthesis of a key chiral bromolactone, application of an interesting cyclization reaction utilizing neighboring group participation to construct a differentially protected 1,2-cis-diamine, and implementation of plug-flow reactor technology to enable the reaction of an unstable intermediate on multihundred kilogram scale. The overall yield for the preparation of edoxaban was significantly increased by implementing these changes and led to a more efficient and environmentally friendly manufacturing process.

Imide intermediate compound as well as preparation method and application thereof

-

Paragraph 0034; 0037, (2018/12/13)

The invention discloses an imide intermediate compound adopting a structure shown as a formula (II) and a preparation method of the imide intermediate compound. The imide intermediate compound can beused as an intermediate for preparing a precursor compound of an anticoagulant edoxaban. The preparation method comprises the following steps: adding a compound adopting a structure shown as a formula(I) into a reaction solvent, introducing a compound containing a nucleophilic amino group into a compound adopting the structure shown as the formula (I) under the action of an azo reagent and ternary substituted phosphorus, converting a hydroxyl group at 1st position into an amino group, and reversing the configuration to obtain the intermediate adopting the structure shown as the formula (II);adding the imide intermediate in alkali, and removing a protecting group to obtain the precursor compound, adopting the structure shown as a formula (III), of the edoxaban. Use of explosive or highlytoxic compounds in the preparation process and a subsequent high-pressure hydrogenation reaction are avoided, not only the chiral purity of a product is greatly improved, but also the production costcan be reduced, safety hazards in the production process are solved, the production cycle is greatly shortened, and the production efficiency is significantly improved.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 365998-36-3