366016-86-6Relevant articles and documents
Discovery of novel and potent CRTH2 antagonists
Ito, Shinji,Terasaka, Tadashi,Zenkoh, Tatsuya,Matsuda, Hiroshi,Hayashida, Hisashi,Nagata, Hiroshi,Imamura, Yoshimasa,Kobayashi, Miki,Takeuchi, Makoto,Ohta, Mitsuaki
, p. 1194 - 1197 (2012/03/11)
High throughput screening of our chemical library for CRTH2 antagonists provided a lead compound 1a. Initial optimization of the lead led to the discovery of a novel, potent and orally bioavailable CRTH2 antagonist 17.
MEDICINAL COMPOSITIONS IMPROVED IN SOLUBLITY IN WATER
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Page/Page column 34, (2010/11/29)
Solid dispersions are provided comprising an HER2 inhibitor which is hardly or not soluble in water and a hydrophilic polymer. These solid dispersions have been improved in the solubility of the HER2 inhibitor, oral absorption and bioavailability in blood
Heterocyclic compounds their production and use
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, (2008/06/13)
A compound represented by the formula: wherein m is 1 or 2, R1 is a halogen or an optionally halogenated C1-2 alkyl; one of R2 and R3 is a hydrogen atom and the other is a group represented by the formula: wherein n is 3 or 4; R4 is a C1-4 alkyl group substituted by 1 or 2 hydroxy groups, or a salt thereof shows tyrosine kinase-inhibiting activity.