36700-45-5 Usage
Description
8-SHOGAOL, a bioactive component derived from ginger (Zingiber officinale), is known for its potent anti-inflammatory properties. It functions as a cyclooxygenase-2 (COX-2) inhibitor, which plays a significant role in the regulation of inflammation and pain.
Uses
Used in Pharmaceutical Industry:
8-SHOGAOL is used as an anti-inflammatory agent for its ability to inhibit COX-2, a key enzyme involved in the production of prostaglandins that contribute to inflammation and pain. This application is particularly relevant in the development of medications for conditions characterized by chronic inflammation, such as arthritis.
Used in Nutraceutical Industry:
8-SHOGAOL is used as a natural supplement for its anti-inflammatory and potential pain-relieving properties. It can be incorporated into dietary supplements and functional foods to support overall health and well-being, particularly for individuals seeking natural alternatives to manage inflammation and related discomfort.
Used in Cosmetics Industry:
8-SHOGAOL may also be used as an ingredient in the cosmetics industry, where its anti-inflammatory properties can be harnessed for products aimed at reducing skin inflammation, redness, and irritation. This application can be particularly beneficial for individuals with sensitive or acne-prone skin, as well as those seeking natural and effective skincare solutions.
Check Digit Verification of cas no
The CAS Registry Mumber 36700-45-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,7,0 and 0 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 36700-45:
(7*3)+(6*6)+(5*7)+(4*0)+(3*0)+(2*4)+(1*5)=105
105 % 10 = 5
So 36700-45-5 is a valid CAS Registry Number.
InChI:InChI=1/C19H28O3/c1-3-4-5-6-7-8-9-10-17(20)13-11-16-12-14-18(21)19(15-16)22-2/h9-10,12,14-15,21H,3-8,11,13H2,1-2H3/b10-9+
36700-45-5Relevant articles and documents
First enantioselective synthesis of gingesulfonic acids and unequivocal determination of their absolute stereochemistry
Adamo, Mauro F. A.,Bencivenni, Grazia,Gillick-Healy, Malachi W.,Kelly, Brian G.,Moccia, Maria,Ravelli, Andrea
supporting information, p. 1091 - 1094 (2020/02/22)
Herein we report the first organocatalysed enantioselective synthesis of gingesulfonic acids and shogasulfonic acids via a mild and convenient aminothiourea-catalysed conjugate addition of bisulfite to the olefin moiety of α,β-unsaturated carbonyls - a technology previously reported by us. A series of optically active naturally occurring sulfonic acids are prepared in their natural and unnatural configurations, and their absolute configurations are unequivocally confirmed by single crystal X-ray diffractometry.
Pharmaceutical compositions useful in prevention and treatment of beta-Amyloid protein-induced disease
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Page/Page column 23; sheet 7, (2008/06/13)
The invention provides methods for treating beta-Amyloid protein-induced disease, pharmaceutical compositions and compounds useful for the same, and the use of these compounds for the manufacture of a medicament for treating the same. More particularly, the invention relates to the use of natural product compounds isolated from turmeric, gingko biloba, and ginger, and synthetic chemical analogues thereof, for the treatment of a beta-Amyloid protein-induced disease.
A convenient one-step gingerol synthesis
Fleming,Dyer,Eggington
, p. 1933 - 1939 (2007/10/03)
Racemic 6-gingerol can be obtained in a one-pot reaction by hexanal addition to the dianion of zingerone at low temperature. Similarly, addition of octanal or decanal to the dianion provides 8-gingerol or 10-gingerol, respectively. Acid treatment of the gingerols allows for formation of the corresponding shogaols.
