36763-96-9Relevant articles and documents
Indolyl compounds and their use in treatment of cephalic pain
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, (2008/06/13)
The invention relates to indoles of general formula (I) STR1 wherein R0 represents a hydrogen atom or a C1-3 alkyl group; R1 represents a group R4 CONH--, R4 R5 NSO2 --, R4 SO2 NH-- or R4 R5 NCO-- (where R4 is a hydrogen atom or a C1-6 alkyl group, provided that R4 does not represent a hydrogen atom when R1 represents R4 SO2 NH--, and R5 is a hydrogen atom or a C1-6 alkyl, C3-7 cycloalkyl, phenyl or phen(C1-3)alkyl group in which the phenyl ring is optionally substituted by a halogen atom or a C1-4 alkoxy, hydroxy or C1-3 alkyl group); R2 is a hydrogen atom, a C1-3 alkyl, a C3-6 alkenyl, a phenyl or a phen(C1-3)alkyl group; R3 is a hydrogen atom, a C1-3 alkyl group or a group --CO2 R6, --COR6, --COCO2 R6 or --CONHR 6 where R6 is a hydrogen atom or a C1-4 alkyl, a C3-7 cycloalkyl, a C3-6 alkenyl, an aryl or an ar(C1-4)alkyl group in which the aryl group may be unsubstituted or substituted by a halogen atom or a C1-4 alkoxy, C1-4 alkyl or hydroxy group, provided that when R3 is --CO2 R6, R6 is other than hydrogen; n is zero or an integer from 1 to 5; and pharmaceutically acceptable salts thereof.