Welcome to LookChem.com Sign In|Join Free

CAS

  • or

36794-52-2

Post Buying Request

36794-52-2 Suppliers

Recommended suppliersmore

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

36794-52-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 36794-52-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,7,9 and 4 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 36794-52:
(7*3)+(6*6)+(5*7)+(4*9)+(3*4)+(2*5)+(1*2)=152
152 % 10 = 2
So 36794-52-2 is a valid CAS Registry Number.
InChI:InChI=1/C19H23N.C4H4O4/c1-4-10-17(11-5-1)16-19(18-12-6-2-7-13-18)20-14-8-3-9-15-20;5-3(6)1-2-4(7)8/h1-2,4-7,10-13,19H,3,8-9,14-16H2;1-2H,(H,5,6)(H,7,8)/b;2-1-

36794-52-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name but-2-enedioic acid,1-(1,2-diphenylethyl)piperidine

1.2 Other means of identification

Product number -
Other names 1,2-diphenyl-1-piperidinoethane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:36794-52-2 SDS

36794-52-2Synthetic route

N-benzoylpiperidine
776-75-0

N-benzoylpiperidine

benzylmagnesium chloride
6921-34-2

benzylmagnesium chloride

(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

Conditions
ConditionsYield
Stage #1: N-benzoylpiperidine With bis(triphenylphosphine)carbonyliridium(I) chloride; 1,1,3,3-Tetramethyldisiloxane In dichloromethane at 20℃; for 0.333333h;
Stage #2: benzylmagnesium chloride at -78 - 20℃; for 4h; chemoselective reaction;
95%
piperidine
110-89-4

piperidine

benzyl bromide
100-39-0

benzyl bromide

benzaldehyde
100-52-7

benzaldehyde

(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

Conditions
ConditionsYield
Stage #1: piperidine; benzyl bromide; benzaldehyde With trifluoroacetic acid; zinc In acetonitrile for 1.5h; Mannich type reaction; Inert atmosphere;
Stage #2: With ammonium chloride In water; acetonitrile
77%
1,1'-benzylidenedipiperidine
2538-76-3

1,1'-benzylidenedipiperidine

benzyl bromide
100-39-0

benzyl bromide

(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

Conditions
ConditionsYield
With chloro-trimethyl-silane; diisopropylamine; zinc In benzene at 20℃; for 6h;46%
1-(butoxyphenylmethyl)piperidine
5351-11-1

1-(butoxyphenylmethyl)piperidine

phenylmagnesium bromide
1589-82-8

phenylmagnesium bromide

(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

Conditions
ConditionsYield
With diethyl ether
benzylmagnesium chloride
6921-34-2

benzylmagnesium chloride

α-piperidino-phenylacetic acid nitrile

α-piperidino-phenylacetic acid nitrile

(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

piperidine
110-89-4

piperidine

benzyl(bromo)zinc
62673-31-8

benzyl(bromo)zinc

benzaldehyde
100-52-7

benzaldehyde

(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

Conditions
ConditionsYield
In acetonitrile at 20℃; for 3h;
piperidine
110-89-4

piperidine

(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: mercury (II)-chloride; calcium sulfate
2: diethyl ether
View Scheme
Multi-step reaction with 3 steps
1: benzene / Unter Entfernen des entstehenden Wassers.
2: potassium carbonate
3: diethyl ether
View Scheme
1,1'-benzylidenedipiperidine
2538-76-3

1,1'-benzylidenedipiperidine

(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium carbonate
2: diethyl ether
View Scheme
benzaldehyde
100-52-7

benzaldehyde

(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: mercury (II)-chloride; calcium sulfate
2: diethyl ether
View Scheme
1,5-dibromo-pentane
111-24-0

1,5-dibromo-pentane

(R,S)-1,2-diphenylethylamine
25611-78-3

(R,S)-1,2-diphenylethylamine

(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃; for 72h; Inert atmosphere;
piperidine
110-89-4

piperidine

diphenyl acetylene
501-65-5

diphenyl acetylene

(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Mor-DaIPhos-AuCl; silver tetrakis(pentafluorophenyl)borate / toluene / 16 h / 110 °C / Inert atmosphere; Sealed cap
2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 20 °C
View Scheme
(E)-1-(1,2-diphenylvinyl)piperidine

(E)-1-(1,2-diphenylvinyl)piperidine

(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃;167 mg
cis-Stilbenyl-diisobutyl-aluminium
20259-38-5, 26076-78-8

cis-Stilbenyl-diisobutyl-aluminium

(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: copper(l) chloride / tetrahydrofuran / 0.5 h / 22 °C / Inert atmosphere
2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 12 h / 22 °C / Inert atmosphere
View Scheme
diphenyl acetylene
501-65-5

diphenyl acetylene

(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: bis(triphenylphosphine)nickel(II) chloride / hexane / 12 h / 60 °C / Inert atmosphere
2: copper(l) chloride / tetrahydrofuran / 0.5 h / 22 °C / Inert atmosphere
3: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 12 h / 22 °C / Inert atmosphere
View Scheme
C19H21N

C19H21N

(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 22℃; for 12h; Inert atmosphere;63.5 mg
(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

(+/-)-1-(1,2-diphenylethyl)piperidine hydrochloride
28383-15-5

(+/-)-1-(1,2-diphenylethyl)piperidine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water at 4 - 40℃;
(±)-1-(1,2-diphenylethyl)piperidine
36794-52-2

(±)-1-(1,2-diphenylethyl)piperidine

(+)-diphenidine

(+)-diphenidine

(-)-diphenidine

(-)-diphenidine

Conditions
ConditionsYield
With carboxymethyl-β-cyclodextrin (degree of substitution: 0.5) In aq. phosphate buffer at 25℃; pH=2.5; Reagent/catalyst; Resolution of racemate;

36794-52-2Relevant articles and documents

Tertiary amine synthesis: Via reductive coupling of amides with Grignard reagents

Xie, Lan-Gui,Dixon, Darren J.

, p. 7492 - 7497 (2017/10/30)

A new iridium catalyzed reductive coupling reaction of Grignard reagents and tertiary amides affording functionalised tertiary amine products via an efficient and technically-simple one-pot, two-stage experimental protocol, is reported. The reaction-which can be carried out on gram-scale using as little as 1 mol% Vaska's complex [IrCl(CO)(PPh3)2] and TMDS as the terminal reductant for the initial reductive activation step-tolerates a broad range of tertiary amides from (hetero)aromatic to aliphatic (branched, unbranched and formyl) and a wide variety of alkyl (linear, branched), vinyl, alkynyl and (hetero)aryl Grignard reagents. The new methodology has been applied directly to bioactive molecule synthesis and the high chemoselectivity of the reductive coupling of amide has been exploited in late stage functionalization of drug molecules. This reductive functionalisation of tertiary amides provides a new and practical solution to tertiary amine synthesis.

Stereo- and regioselective gold-catalyzed hydroamination of internal alkynes with dialkylamines

Hesp, Kevin D.,Stradiotto, Mark

supporting information; experimental part, p. 18026 - 18029 (2011/03/16)

We report the use of a P,N-ligand to support a gold complex as a state-of-the-art precatalyst for the stereoselective hydroamination of internal aryl alkynes with dialkylamines to afford E-enamine products. Substrates featuring a diverse range of functional groups on both the amine (ether, sulfide, N-Boc amine, fluoro, nitrile, nitro, alcohol, N-heterocycles, amide, ester, and carboxylic acid) and alkyne (ether, N-heterocycles, N-phthalimide amines, and silyl ethers) are accommodated with synthetically useful regioselectivity.

NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds

Berger, Michael L.,Schweifer, Anna,Rebernik, Patrick,Hammerschmidt, Friedrich

experimental part, p. 3456 - 3462 (2009/09/30)

We resolved 1,2-diphenylethylamine (DPEA) into its (S)- and (R)-enantiomer and used them as precursors for synthesis of (S)- and (R)-1-(1,2-diphenylethyl)piperidine, flexible homeomorphs of the NMDA channel blocker MK-801. We also describe the synthesis o