36814-62-7

Basic information

• Product Name: Acetic acid, [(phenylethynyl)thio]-, methyl ester
• CAS NO: 36814-62-7
• Molecular Formula: C11H10O2S
• Molecular Weight: 206.265
• Mol File: 36814-62-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetic acid, [(phenylethynyl)thio]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, [(phenylethynyl)thio]-, methyl ester(36814-62-7)
• EPA Substance Registry System: Acetic acid, [(phenylethynyl)thio]-, methyl ester(36814-62-7)

Safety Data

• Hazardous Substances Data: 36814-62-7(Hazardous Substances Data)

Upstream product

• 2365-48-2 Methyl thioglycolate 
• 6832-16-2 methyl diazoacetate 
• 14476-62-1 1-Ethylthio-2-phenyl-acetylen 
• 25445-77-6 4-phenyl-1,2,3-thiadiazole 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 18212-39-0 (2-Phenyl-ethinyl-⁽¹⁾)-thio-essigsaeure 

Relevant articles and documents

5-(Alkynyl)dibenzothiophenium Triflates: Sulfur-Based Reagents for Electrophilic Alkynylation

The synthesis of a series of 5-(alkynyl) dibenzothiophenium triflates, prepared from dibenzo[b,d]thiophene 5-oxide and the corresponding trimethylsilyl-substituted alkynes is reported. Their structures were determined by X-ray crystallography, and their reactivities as electrophilic alkynylation reagents evaluated. Their broad substrate scope and functional-group tolerance illustrate their potential to become an alternative to the broadly used EBX reagents. Isotope labeling studies reveal that alkynyldibenzothiophenium salts may undergo attack by nucleophiles at either the α- or β-carbon atom depending on the nature of their substitution pattern. Subsequent elimination of the dibenzothiophene unit and 1,2-migration of one of the groups (in case of β-attack) affords the desired alkynes.

Unsaturated thioacetic acids as novel mechanism-based inhibitors of peptidylglycine α-hydroxylating monooxygenase

Several unsaturated thioacetic acids were synthesized as potential mechanism-based inhibitors of peptidylglycine α-hydroxylating monooxygenase (PHM) prepared from horse serum. Trans-styrylthioacetic acid produced potent time-dependent inhibition of PHM. Potential mechanisms are proposed to explain PHM inactivation by unsaturated thioacetic acids.