368430-64-2

Basic information

• Product Name: Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5,6,7,8-tetrahydro-1,3,8-trimethyl-5-[(2-methylphenoxy)methylene]-, (5E)-
• CAS NO: 368430-64-2
• Molecular Formula: C18H21N3O3
• Molecular Weight: 327.383
• Mol File: 368430-64-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5,6,7,8-tetrahydro-1,3,8-trimethyl-5-[(2-methylphenoxy)methylene]-, (5E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5,6,7,8-tetrahydro-1,3,8-trimethyl-5-[(2-methylphenoxy)methylene]-, (5E)-(368430-64-2)
• EPA Substance Registry System: Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, 5,6,7,8-tetrahydro-1,3,8-trimethyl-5-[(2-methylphenoxy)methylene]-, (5E)-(368430-64-2)

Safety Data

• Hazardous Substances Data: 368430-64-2(Hazardous Substances Data)

Upstream product

• 84814-02-8 4-chloro-1-(2-methylphenyloxy)but-2-yne 
• 6972-27-6 1,3-Dimethyl-6-chlorouracil 
• 368430-55-1 1,3-dimethyl-6-[methyl-(4-o-tolyloxy-but-2-ynyl)-amino]-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Synthesis of bioactive heterocycles: Sigmatropic rearrangements of 1,3-dimethyl-6-[methyl(4-aryloxybut-2-ynyl)amino]pyrimidine-2,4(1H,3H)-diones

A number of 1,3-dimethyl-6-[methyl (4-aryloxybut-2-ynyl)amino]pyrimidine-2,4(1H,3H)-diones 4a-i were synthesised in 69 to 80% yields by the reaction of 6-chloro-1,3-dimethyluracil (6-chloro-1,3-dimethylpyrimidine-2,4(1H, 3H)-diones) and 1-aryloxy-4-N-methylaminobut-2-yne in refluxing ethanol for 12 hours. The tertiary amines 4a-i were then heated in refluxing 1,2-dichlorobenzene for 17 hours to give 5-[(E)-aryloxymethylidene]-1,3,8-trimethyl-5,6,7,8-tetrahydropyrido[2,3-d] pyrimidine-2,4(1H,3H)- diones 5a-i in 55 to 75% yields.