36861-47-9 Usage
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 36861-47-9 differently. You can refer to the following data:
1. 3-(4-Methylbenzylidene)camphor is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation. 4-Methylbenzylidene camphor(4-MBC) a UV-B ray filter, is an endocrine disruptors (ED).
2. 3-(4-Methylbenzyliden)camphor is an UV-B absorbing agent in sunscreen cosmetics of the type creams, lotions, lipsticks, sun oils, etc.
3. 4-(Methylbenzylidene)camphor (4-MBC), a UV-B ray filter, is an endocrine disruptors (ED).
Biological Activity
4-methylbenzylidene camphor (4-mbc) is an ultraviolet light blocker used in cosmetics and sunscreen preparations that also has estrogenic activities.since the estrogen receptor (er) ligand type can influence transactivation, it is important to obtain information on molecular actions of nonclassical er agonists.
in vitro
previous results of competitive binding assays using cytosolic protein preparations from xenopus hepatocytes demonstrated that 4-mbc could weakly bind to the er. in addition, 4-mbc at a 100 micromol/l was not able to replace estradiol from the receptor completely [1].
in vivo
the estrogen target gene expression in uterus of long evans rats after exposure to 4-mbc was studied. results showed that 4-mbc could altere steady-state levels of mrnas encoding for er, progesterone receptor (pr), and androgen recepto in uterus of 12-wk-old offspring. to evaluate sensitivity to estradiol (e2), offspring were injected with e2, and killed 6 h later. acute up-regulation of pr and igf-i and down-regulation of er and androgen receptor by e2 were reduced in 4-mbc treated rats dose-dependently [2].
references
[1] klann a, levy g, lutz i, müller c, kloas w, hildebrandt jp. estrogen-like effects of ultraviolet screen 3-(4-methylbenzylidene)-camphor (eusolex 6300) on cell proliferation and gene induction in mammalian and amphibian cells. environ res. 2005 mar;97(3):274-81.[2] s. durrer, k. maerkel, m. schlumpf, et al. estrogen target gene regulation and coactivator expression in rat uterus after developmental exposure to the ultraviolet filter 4-methylbenzylidene camphor. endocrinology 146(5), 2130-2139 (2005).[3] n. r. janjua, b. mogensen, a. m. andersson, et al. systemic absorption of the sunscreens benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole-body topical application and reproductive hormone levels in humans. journal of investigative dermatology 123, 57-61(2004).
Check Digit Verification of cas no
The CAS Registry Mumber 36861-47-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,8,6 and 1 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 36861-47:
(7*3)+(6*6)+(5*8)+(4*6)+(3*1)+(2*4)+(1*7)=139
139 % 10 = 9
So 36861-47-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H22O/c1-12-5-7-13(8-6-12)11-14-15-9-10-18(4,16(14)19)17(15,2)3/h5-8,11,15H,9-10H2,1-4H3
36861-47-9Relevant articles and documents
Use of benzazoles UV absorbers, new benzazoles and a process for their preparation
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, (2008/06/13)
Compounds which, per molecule, contain at least 2 benzazolyl groups are outstandingly suitable as UV absorbers for sunscreen compositions.
Cosmetic screening composition containing a UV screen in combination with a polymer obtained by block polymerization in emulsion and its use for the protection of the human epidermis against ultraviolet radiations
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, (2008/06/13)
Cosmetic screening composition containing a UV screen in combination with a polymer obtained by block polymerization in emulsion and its use for the protection of the human epidermis against ultraviolet radiations.
