368886-04-8

Basic information

• Product Name: C-(5,5-diphenyl-4,5-dihydro-isoxazol-3-yl)-methylamine
• CAS NO: 368886-04-8
• Molecular Weight: 252.316
• Mol File: 368886-04-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C-(5,5-diphenyl-4,5-dihydro-isoxazol-3-yl)-methylamine(CAS DataBase Reference)
• NIST Chemistry Reference: C-(5,5-diphenyl-4,5-dihydro-isoxazol-3-yl)-methylamine(368886-04-8)
• EPA Substance Registry System: C-(5,5-diphenyl-4,5-dihydro-isoxazol-3-yl)-methylamine(368886-04-8)

Safety Data

• Hazardous Substances Data: 368886-04-8(Hazardous Substances Data)

Upstream product

• 163520-33-0 isoxadifen-ethyl 
• 530-48-3 1,1-Diphenylethylene 

Relevant articles and documents

Anti-influenza virus activities of 2-alkoxyimino-N-(2-isoxazolin-3-ylmethyl)acetamides

A series of 2-alkoxyimino-N-(2-isoxazolin-3-ylmethyl)acetamides and related compounds were synthesized and their antiviral activities against human influenza A virus were assessed. Studies of the structure-activity relationships revealed the strongest antiviral activity when position-5 of the isoxazoline ring was substituted with a tert-butyl group. When the alkoxyimino moiety was substituted with a methyl, ethyl, isopropyl or allyl group, good antiviral activity was obtained. Among the geometrical isomers at the oxime moiety, the E-isomers were more active than the Z-isomers. Among the compounds examined, (E)-2-allyloxyimino-2-cyano-N-(5-tert-butyl-2-isoxazolin-3-ylmethyl)acetamide (1j) was the most active inhibitor with an EC50 of 3 μg/mL in vitro.