370104-34-0Relevant articles and documents
The design and synthesis of a novel, orally active, selective ETA antagonist
Rawson, David J.,Dack, Kevin N.,Dickinson, Roger P.,James, Kim,Long, Clive,Walker, Don
, p. 149 - 157 (2004)
The potency and pharmacokinetic properties of an indole-based series of endothelin antagonists have been optimised using in vitro, in silico and in vivo methods. Compound 8 is oxidised in vivo to the active metabolite 7 and has been highlighted as an oral