3709-98-6

Basic information

• Product Name: 4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI)
• Synonyms: 4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI);2-Ethyl-4,6-pyrimidinediol;2-Ethyl-6-hydroxy-4(3H)-pyrimidinone;4(1H)-PyriMidinone, 2-ethyl-6-hydroxy-;2-ethylpyriMidine-4,6-diol;2-ethyl-6-hydroxy-3H-pyrimidin-4-one;2-ethyl-6-hydroxypyrimidin-4(1H)-one
• CAS NO: 3709-98-6
• Molecular Formula: C₆H₈N₂O₂
• Molecular Weight: 140.13992
• Product Categories: PYRIMIDINE
• Mol File: 3709-98-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: >280℃
• Boiling Point: 313.8ºC at 760 mmHg
• Flash Point: 143.6ºC
• Appearance: /
• Density: 1.35
• Vapor Pressure: 0.000264mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 6.46±0.10(Predicted)
• CAS DataBase Reference: 4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI)(3709-98-6)
• EPA Substance Registry System: 4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI)(3709-98-6)

Safety Data

• Hazardous Substances Data: 3709-98-6(Hazardous Substances Data)

Usage

General Description

4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI) is a chemical compound with the molecular formula C6H8N2O2. It is a derivative of pyrimidinone, and its structure contains an ethyl group and a hydroxyl group attached to the pyrimidinone ring. This chemical is used in the synthesis of various pharmaceuticals and agrochemicals, and it also has potential applications in the fields of organic chemistry and material science. Its physical and chemical properties make it suitable for use as a building block in the production of various organic compounds. Additionally, its structure and reactivity make it a valuable intermediate for the synthesis of diverse functionalized molecules with potential biological and pharmacological activities.

InChI:InChI=1/C6H8N2O2/c1-2-4-7-5(9)3-6(10)8-4/h3H,2H2,1H3,(H2,7,8,9,10)

Upstream product

• 108-59-8 malonic acid dimethyl ester 
• 3599-89-1 propionamidine hydrochloride 
• 105-53-3 diethyl malonate 

Downstream Products

• 1269116-89-3 2-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-7-methyl-4-oxo-3-(2-oxo-2-phenylethyl)-5-(2,2,2-trifluoroethoxy)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 
• 1269118-94-6 ethyl 3-(3-chlorobenzyl)-2-ethyl-7-methyl-5-(1-methylethoxy)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate 
• 1269118-48-0 ethyl 4-chloro-2-ethyl-5-hydroxy-7-methyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate 
• 1269117-06-7 2-ethyl-N-[1-(hydroxyacetyl)piperidin-4-yl]-7-methyl-5-(1-methylethoxy)-4-oxo-3-(2-oxo-2-phenylethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxamide 
• 1195-34-2 4,6-dichloro-2-ethylpyrimidine 

Relevant articles and documents

COMPOUNDS

Disclosed are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis(ALS).

PYRIMIDINE PDE10 INHIBITORS

The present invention is directed to pyrimidine compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.

Pyrimidines substituted by nitrogen-containing heterocyclic rings as intermediates

1,2,4-Triazolo[4,3-c]pyrimidines substituted at the 5 or 7 position through a nitrogen atom which is part of a heterocyclic ring have been found to have potent bronchodilator activity and to be useful synthetic intermediates in the preparation of 1,2,4-triazolo[1,5-c]pyrimidines. Methods for inducing bronchodilation, pharmaceutical compositions, and synthetic processes and intermediates are also described.