371-90-4

Basic information

• Product Name: 1,1-DIFLUOROCYCLOHEXANE
• Synonyms: 1,1-DIFLUOROCYCLOHEXANE;4,4-Difluorocyclohexane;Cyclohexane,1,1-difluoro-
• CAS NO: 371-90-4
• Molecular Formula: C₆H₁₀F₂
• Molecular Weight: 120.14
• Mol File: 371-90-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 95.8°Cat760mmHg
• Flash Point: 4.9°C
• Appearance: /
• Density: 1g/cm³
• Vapor Pressure: 51.1mmHg at 25°C
• Refractive Index: 1.383
• CAS DataBase Reference: 1,1-DIFLUOROCYCLOHEXANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-DIFLUOROCYCLOHEXANE(371-90-4)
• EPA Substance Registry System: 1,1-DIFLUOROCYCLOHEXANE(371-90-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 371-90-4(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 84, p. 4275, 1962 DOI: 10.1021/ja00881a017Tetrahedron, 27, p. 3965, 1971

InChI:InChI=1/C6H10F2/c7-6(8)4-2-1-3-5-6/h1-5H2

Upstream product

• 108-94-1 cyclohexanone 
• 699-64-9 <1-Fluorcyclohexyl>-fluorformiat 
• 2108-92-1 1,1-dichlrocyclohexane 
• 29443-47-8 1,1-diiodocyclohexane 
• 695-64-7 1-chloro-1-nitrosocyclohexane 
• 407-25-0 trifluoroacetic anhydride 
• 95652-97-4 1,1-diacetoxycyclohexane 
• 22780-08-1 1,1-bis(trichloroacetoxy)cyclohexane 
• 694-51-9 1-fluorocyclohexene 
• 115869-06-2 1,1-bis(trifluoroacetoxy)cyclohexane 
• 1528-30-9 methylenecyclopentane 
• 100-64-1 cyclohexanone-oxime 
• 930-66-5 1-chlorocyclohexene 

Downstream Products

• 462-06-6 fluorobenzene 
• 110-83-8 cyclohexene 
• 71-43-2 benzene 
• 110-82-7 cyclohexane 
• 694-51-9 1-fluorocyclohexene 
• 2108-92-1 1,1-dichlrocyclohexane 

Relevant articles and documents

METHOD FOR MANUFACTURING DIFLUOROMETHYLENE COMPOUND

The problem to be solved by the present invention is to provide a novel method for producing a difluoromethylene compound. This problem is solved by a method for producing a difluoromethylene compound containing a —CF2— moiety, the method comprising step A of mixing: a) a carbonyl compound containing a —C(O)— moiety;b) optionally an amine;c) a fluoride represented by the formula: MF, wherein M represents a Group 1 element of the periodic table;d) a halogenated fluorine compound represented by the formula: XFn, wherein X represents chlorine, bromine, or iodine, and n is a natural number of 1 to 5; ande) sulfur chloride.

Practical synthesis of gem-difluorides from cyclohexanone: Synthesis of gem-bistrifluoroacetates and their reactions with fluoride nucleophiles

Formation of ketone acylals bearing trihaloacetoxy groups and their nucleophilic geminal disubstitution by fluoride ions were investigated. Cyclohexanone reacted with trifluoroacetic anhydride without catalyst to give gem-bistrifluoroacetates via a concerted bimolecular reaction. Treatment with hydrogen fluoride under mild conditions efficiently yielded the corresponding gem-difluorides. In this reaction process, trifluoroacetic acid was recovered and converted to trifluoroacetic anhydride using P2O5. Since gem-difluorides were derived from ketones, HF and P2O5, this constitutes a practical synthesis of gem-difluorides.

FLUORINATION PROCESSES WITH ARYLSULFUR HALOTETRAFLUORIDES

New fluorination processes for introducing one or more fluorine atoms into target substrate compounds with arylsulfur halotetrafluorides are disclosed. Also disclosed are methods for preparation of arylsulfur trifluorides.