3717-60-0

Basic information

• Product Name: N-Benzyl-1-aminoadamantane
• Synonyms: N-Benzyl-1-aminoadamantane;N-(1-adamantyl)-N-benzylamine
• CAS NO: 3717-60-0
• Molecular Formula: C₁₇H₂₃N
• Molecular Weight: 241.37
• Mol File: 3717-60-0.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 352.2 °C at 760 mmHg
• Flash Point: 172.4 °C
• Appearance: /
• Density: 1.07 g/cm³
• CAS DataBase Reference: N-Benzyl-1-aminoadamantane(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl-1-aminoadamantane(3717-60-0)
• EPA Substance Registry System: N-Benzyl-1-aminoadamantane(3717-60-0)

Safety Data

• Hazardous Substances Data: 3717-60-0(Hazardous Substances Data)

Usage

General Description

N-Benzyl-1-aminoadamantane is a chemical compound that belongs to the class of adamantane derivatives. It is composed of an adamantane core, which is a diamondoid molecule, with a benzyl group attached to the nitrogen atom. N-Benzyl-1-aminoadamantane has potential pharmacological properties, as it has been studied for its potential as a dopamine reuptake inhibitor and a potential treatment for Parkinson's disease. Additionally, it has also been investigated for its potential as a drug to treat addiction to stimulants. The presence of the benzyl group in its structure provides it with unique chemical and biological properties, making it a potential candidate for the development of new therapeutic agents.

Upstream product

• 768-94-5 1-Adamantanamine 
• 100-46-9 benzylamine 
• 103-49-1 dibenzylamine 
• 24886-73-5 1-Azidoadamantane 
• 108-88-3 toluene 
• 100-47-0 benzonitrile 
• 1613073-63-4 C₁₇H₂₃NO 
• 100-52-7 benzaldehyde 
• 100-51-6 benzyl alcohol 
• 1215209-26-9 [Cl₂NN]Cu-NHAd 
• 665-66-7 amantadine hydrochloride 
• 57527-54-5 N-(-adamantan-1-yl)-1-phenylmethanimine 

Downstream Products

• 79750-14-4 N-benzyl-N-(2-hydroxyethyl)-1-adamantylamine 
• 1613073-58-7 N-propargyl-N-benzyl-adamantan-1-amine 
• 3716-66-3 1-(2-hydroxyethylamino)adamantane 
• 31463-28-2 N-adamantyl-α-phenylnitrone 
• 31463-28-2 N-(Phenylmethylene)tricyclo<3.3.1.1^3,7>decan-1-amine N-Oxide 

Relevant articles and documents

Cobalt complex, preparation method thereof, and application thereof in selective catalysis of transfer hydrogenation reaction of cyano group

The invention discloses a cobalt complex, a preparation method thereof, and an application thereof in the selective catalysis of a transfer hydrogenation reaction of a cyano group. The structural formula of the cobalt complex is represented by formula I. The cobalt complex is prepared through a reaction of a cobalt salt and an NNP ligand or a PNP ligand under the protection of an inert atmosphere;and the chemical formula of the cobalt salt is CoX12, wherein X1 represents halogen, a sulfate radical, a perchlorate radical, a hexafluorophosphate radical, a hexafluoroantimonate radical, a tetrafluoroborate radical, a trifluoromethanesulfonate radical or a tetra(pentafluorophenyl)borate radical. The cobalt complex can be used in the selective catalysis of the transfer hydrogenation reaction ofthe cyano group to obtain a primary amine compound, a secondary amine compound and a tertiary amine compound, the primary amine compound, the secondary amine compound and the tertiary amine compoundare important intermediates in a series of subsequent functionalizing reactions, and the cobalt complex has a very high catalysis activity, and has great research values and a great application prospect.

High-Spin Iron Imido Complexes Competent for C-H Bond Amination

Reduction of previously reported (ArL)FeCl with potassium graphite furnished a low-spin (S = 1/2) iron complex (ArL)Fe which features an intramolecular η6-arene interaction and can be utilized as an FeI synthon (ArL = 5-mesityl-1,9-(2,4,6-Ph3C6H2)dipyrrin). Treatment of (ArL)Fe with adamantyl azide or mesityl azide led to the formation of the high-spin (S = 5/2), three-coordinate imidos (ArL)Fe(NAd) and (ArL)Fe(NMes), respectively, as determined by EPR, zero-field 57Fe M?ssbauer, magnetometry, and single crystal X-ray diffraction. The high-spin iron imidos are reactive with a variety of substrates: (ArL)Fe(NAd) reacts with azide yielding a ferrous tetrazido (ArL)Fe(κ2-N4Ad2), undergoes intermolecular nitrene transfer to phosphine, abstracts H atoms from weak C-H bonds (1,4-cyclohexadiene, 2,4,6-tBu3C6H2OH) to afford ferrous amido product (ArL)Fe(NHAd), and can mediate intermolecular C-H amination of toluene [PhCH3/PhCD3 kH/kD: 15.5(3); PhCH2D kH/kD: 11(1)]. The C-H bond functionalization reactivity is rationalized from a two-step mechanism wherein each step occurs via maximal energy and orbital overlap between the imido fragment and the C-H bond containing substrate.

Mild and Selective Cobalt-Catalyzed Chemodivergent Transfer Hydrogenation of Nitriles

Herein, we describe a selective cobalt-catalyzed chemodivergent transfer hydrogenation of nitriles to synthesize primary, secondary, and tertiary amines. The solvent effect plays a key role for the selectivity control. The general applicability of this procedure was highlighted by the synthesis of more than 70 amine products bearing various functional groups in high chemoselectivity. Moreover, this mild system achieved >2000 TONs (turnover numbers) for the transfer hydrogenation of nitriles.