372077-49-1

Basic information

• Product Name: 5-Methoxy-1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine
• Synonyms: 5-Methoxy-1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine;1-(Phenylsulfonyl)-5-Methoxy-4-azaindole ;1H-Pyrrolo[3,2-b]pyridine, 5-Methoxy-1-(phenylsulfonyl)-;1-benzenesulfonyl-5-methoxy-1H-pyrrolo[3,2-b]pyridine
• CAS NO: 372077-49-1
• Molecular Formula: C₁₄H₁₂N₂O₃S
• Molecular Weight: 288.32168
• Mol File: 372077-49-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 128℃
• Appearance: /
• Density: 1.34
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Methoxy-1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxy-1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine(372077-49-1)
• EPA Substance Registry System: 5-Methoxy-1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine(372077-49-1)

Safety Data

• Hazardous Substances Data: 372077-49-1(Hazardous Substances Data)

Usage

Description

5-Methoxy-1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine is a chemical compound with the molecular formula C17H14N2O3S. It is a highly potent and selective inhibitor of the protein kinase family, with potential applications in cancer treatment and drug development.

Uses

Used in Cancer Treatment:
5-Methoxy-1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine is used as an anticancer agent for its ability to effectively inhibit tumor growth and metastasis. Its unique structure and powerful inhibitory effects make it a valuable tool for researchers studying protein kinases and their role in cancer and other diseases.
Used in Drug Development:
5-Methoxy-1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine is used as a lead compound in the development of new and improved therapies for various types of cancer and other conditions. Its promising results in preclinical studies suggest that further research and development may lead to the creation of innovative treatments.

Upstream product

• 98-09-9 benzenesulfonyl chloride 
• 17288-40-3 5-methoxy-4-aza-1H-indole 
• 5446-92-4 2-methoxy-5-nitropyridine 
• 111795-99-4 2-(6-methoxy-3-nitropyridin-2-yl)acetonitrile 

Downstream Products

• 1206181-32-9 C₁₄H₁₁⁽²⁾HN₂O₃S 
• 1206181-35-2 C₁₄H₁₀⁽²⁾H₂N₂O₃S 
• 1206181-53-4 1-benzenesulfonyl-5-methoxy-1H-pyrrolo[3,2-b]pyridine-2-boronic acid 
• 1206181-42-1 1-benzenesulfonyl-2-iodo-5-methoxy-1H-pyrrolo[3,2-b]pyridine 
• 1206181-45-4 1-benzenesulfonyl-5-methoxy-1H-pyrrolo[3,2-b]pyridine-2-carboxylic acid methyl ester 
• 1206181-39-6 (1-benzenesulfonyl-5-methoxy-1H-pyrrolo[3,2-b]pyridin-2-yl)-(4-bromo-phenyl)-methanol 
• 728006-96-0 (1-benzenesulfonyl-5-methoxy-1H-pyrrolo[3,2-b]pyridin-2-yl)-phenyl-methanone 
• 1206181-48-7 1-benzenesulfonyl-5-methoxy-2-trimethylsilanyl-1H-pyrrolo[3,2-b]pyridine 
• 677302-48-6 1-benzenesulfonyl-1,4-dihydro-5H-pyrrolo[3,2-b]pyridin-5-one 
• 737003-27-9 1-benzenesulfonyl-5-(6-bromohexyloxy)-1H-pyrrolo[3,2-b]pyridine 
• 737003-26-8 1-benzenesulfonyl-5-(5-bromopentyloxy)-1H-pyrrolo[3,2-b]pyridine 
• 737003-25-7 1-benzenesulfonyl-5-(4-bromobutoxy)-1H-pyrrolo[3,2-b]pyridine 

Relevant articles and documents

Convenient access to C-2 or C-5 substituted 4-azaindole derivatives

Functionalization at C-2 and C-5 of N-benzenesulfonyl-4-azaindole 1 was performed by lithiation reactions and original palladium-catalyzed chemistry. It led to very useful new substituted 4-azaindole derivatives in fair to high yields.