372195-85-2

Basic information

• Product Name: 4-Butylpiperidine hydrochloride
• Synonyms: 4-Butylpiperidine hydrochloride
• CAS NO: 372195-85-2
• Molecular Formula: C9H20ClN
• Molecular Weight: 177.7148
• Product Categories: Piperidine
• Mol File: 372195-85-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DCM, Ethyl Acetate
• CAS DataBase Reference: 4-Butylpiperidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Butylpiperidine hydrochloride(372195-85-2)
• EPA Substance Registry System: 4-Butylpiperidine hydrochloride(372195-85-2)

Safety Data

• Hazardous Substances Data: 372195-85-2(Hazardous Substances Data)

Usage

Uses

4-Butylpiperidine Hydrochloride is an intermediate in the synthesis of AC 42 (A115600), an allosteric agonist of acetylcholine orthosteric site.

Upstream product

• 5335-75-1 4-butylpyridine 
• 108-89-4 picoline 

Relevant articles and documents

Efficient Diastereoselective Three-Component Synthesis of Pipecolic Amides

An efficient Ugi-type three-component reaction (U-3CR) for the synthesis of pipecolic amides is reported. The U-3CR between electronically diverse isocyanides, carboxylic acids and 4-substituted Δ1-piperideines proceeds in a highly diastereoselective fashion. The Δ1-piperideines are obtained by NCS-mediated oxidation of the corresponding 4-substituted piperidines, which in turn are generated by an efficient two-step procedure involving the alkylation of 4-picoline and subsequent catalytic hydrogenation of the pyridine ring. We demonstrate the utility of this U-3CR, in combination with the convertible isocyanide 2-bromo-6-isocyanopyridine, in the synthesis of the anticoagulant argatroban.