37244-51-2

Basic information

• Product Name: HISTONE
• Synonyms: HISTONE H4;HISTONE H1 (CALF);HISTONE H1, CALF THYMUS;HISTONE H3;HISTONE TYPE II-S;HISTONE KAP;HISTONE KSA;HISTONES, CALF
• CAS NO: 37244-51-2
• Molecular Weight: 0
• EINECS: 297-235-6
• Mol File: 37244-51-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: 2-8°C
• CAS DataBase Reference: HISTONE(CAS DataBase Reference)
• NIST Chemistry Reference: HISTONE(37244-51-2)
• EPA Substance Registry System: HISTONE(37244-51-2)

Safety Data

• WGK Germany: 3
• RTECS: MS3450700
• F: 10-21
• Hazardous Substances Data: 37244-51-2(Hazardous Substances Data)

Usage

Description

Histone is a mixture of DNA-binding proteins, including histones H1, H2A, H2B, H3, and H4, isolated from calf thymus. These proteins are characterized by relatively high levels of lysine and arginine. The H1 fraction is lysine-rich, while the H2A and H2B are slightly lysine-rich, and the H3 and H4 fractions are arginine-rich. The molecular weights of histones range from approximately 11 to 21 kDa depending on the fraction. Histones play a crucial role in the packaging and organization of DNA within the cell nucleus.

Uses

Used in Biomedical Research:
Histone is used as a research tool for studying the role of histones in various cellular processes, including gene regulation, DNA repair, and chromatin remodeling. The different histone fractions (H1, H2A, H2B, H3, and H4) provide insights into the structure and function of chromatin and its impact on cellular activities.
Used in Cancer Research:
Histone H3 is used as a biomarker to determine the role of histones in metastasis, a critical process in the spread of cancer cells. Understanding the involvement of histones in metastasis can help develop targeted therapies and improve cancer treatment outcomes.
Used in Molecular Biology Techniques:
Histones are used in dot blot and western blotting techniques, which are essential methods for detecting and analyzing specific proteins in a sample. These techniques are widely employed in research and diagnostics to study protein expression, post-translational modifications, and protein-protein interactions.

Biochem/physiol Actions

Histone proteins are basic building blocks of chromatin. Mutations in Histone H3 results in adult cerebellar high-grade gliomas. It controls protein-protein interactions to induce binding of trans-acting factors that “drive” chromatin condensation. H3.1 acts as a replication-dependent histone.