37296-80-3 Usage
Uses
Colestipol Hydrochloride was useful for studying pharmacokinetics with Teriflunomide (A771726).
Definition
ChEBI: The hydrochloride of colestipol, a highly cross-linked, high molecular weight copolymer of diethylenetriamine and epichlorohydrin (hydrochloride), with approximately 1 out of 5 amine nitrogens protonated. It is used for binding bile acids in the intestine,
inhibiting their reabsorption.
General Description
Colestipol (Colestid) is ahigh–molecular-weight, insoluble, granular copolymer oftetraethylenepentamine and epichlorohydrin. It functions asan anion-exchange, resin-sequestering agent in a manner similarto that of cholestyramine resin. Colestipol hydrochloridereduces cholesterol levels without affecting triglycerides andseems to be especially effective in the treatment of type IIhyperlipoproteinemias.
Clinical Use
#N/A
Drug interactions
Potentially hazardous interactions with other drugs
Anticoagulants: may enhance or reduce effects of
coumarins and phenindione.
Ciclosporin: no reports of an interaction; however,
ciclosporin levels should be carefully monitored if
colestipol and ciclosporin are prescribed concurrently,
as colestipol may interfere with ciclosporin
absorption.
Metabolism
Not applicable as colestipol is not systemically absorbed.
Check Digit Verification of cas no
The CAS Registry Mumber 37296-80-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,2,9 and 6 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 37296-80:
(7*3)+(6*7)+(5*2)+(4*9)+(3*6)+(2*8)+(1*0)=143
143 % 10 = 3
So 37296-80-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H23N5.ClH/c9-1-3-11-5-7-13-8-6-12-4-2-10;/h11-13H,1-10H2;1H
