372967-45-8 Usage
Description
(R)-2-(DIBENZYLAMINO)-3-METHYL-1-BUTANOL, with a molecular formula of C20H25NO, is a chiral compound that possesses a non-superimposable mirror image. The "R" designation in its name signifies its specific stereochemistry. (R)-2-(DIBENZYLAMINO)-3-METHYL-1-BUTANOL is widely utilized in organic synthesis and serves as a reagent for chiral resolution. Its structural features, including a benzylamino group and a hydroxyl group, render it a versatile intermediate for the production of a range of organic compounds, particularly in the pharmaceutical and agrochemical industries.
Uses
Used in Organic Synthesis:
(R)-2-(DIBENZYLAMINO)-3-METHYL-1-BUTANOL is used as a key intermediate for the synthesis of various organic compounds due to its unique structural features. Its ability to participate in a range of chemical reactions makes it a valuable asset in the development of new molecules with potential applications in various fields.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, (R)-2-(DIBENZYLAMINO)-3-METHYL-1-BUTANOL is used as a building block in the synthesis of drugs. Its chiral nature and functional groups enable the creation of enantiomerically pure compounds, which are essential for the development of effective and safe medications.
Used in Agrochemical Synthesis:
Similarly, in the agrochemical sector, (R)-2-(DIBENZYLAMINO)-3-METHYL-1-BUTANOL is employed as a versatile intermediate for the synthesis of various agrochemicals, such as pesticides and herbicides. Its unique structure allows for the development of novel compounds with improved efficacy and selectivity.
Used in Chiral Resolution:
(R)-2-(DIBENZYLAMINO)-3-METHYL-1-BUTANOL is also used as a reagent in chiral resolution processes. Its chiral nature allows for the separation of enantiomers, which is crucial in the production of enantiomerically pure compounds, as the biological activity of chiral molecules can often be highly dependent on their stereochemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 372967-45-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,7,2,9,6 and 7 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 372967-45:
(8*3)+(7*7)+(6*2)+(5*9)+(4*6)+(3*7)+(2*4)+(1*5)=188
188 % 10 = 8
So 372967-45-8 is a valid CAS Registry Number.
372967-45-8Relevant articles and documents
Hydrogen-Borrowing Alkylation of 1,2-Amino Alcohols in the Synthesis of Enantioenriched γ-Aminobutyric Acids
Hall, Christopher J. J.,Goundry, William R. F.,Donohoe, Timothy J.
supporting information, p. 6981 - 6985 (2021/03/01)
For the first time we have been able to employ enantiopure 1,2-amino alcohols derived from abundant amino acids in C?C bond-forming hydrogen-borrowing alkylation reactions. These reactions are facilitated by the use of the aryl ketone Ph*COMe. Racemisation of the amine stereocentre during alkylation can be prevented by the use of sub-stoichiometric base and protection of the nitrogen with a sterically hindered triphenylmethane (trityl) or benzyl group. The Ph* and trityl groups are readily cleaved in one pot to give γ-aminobutyric acid (GABA) products as their HCl salts without further purification. Both steps may be performed in sequence without isolation of the hydrogen-borrowing intermediate, removing the need for column chromatography.
MANGANESE-CATALYSED HYDROGENATION OF ESTERS
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Page/Page column 34; 37; 38, (2019/08/06)
The present invention relates to the field of catalytic hydrogenation and, more particularly, to methods of manganese-catalysed hydrogenation of esters to alcohols. Advantageously, where the esters are chiral, the hydrogenations proceed with high or complete stereochemical integrity..
Manganese Catalyzed Hydrogenation of Enantiomerically Pure Esters
Widegren, Magnus B.,Clarke, Matthew L.
supporting information, p. 2654 - 2658 (2018/05/17)
A manganese-catalyzed hydrogenation of esters has been accomplished with TONs up to 1000, using cheap, environmentally benign, potassium carbonate and simple alcohols as activator and solvent, respectively. The weakly basic conditions lead to good functional group tolerance and enable the hydrogenation of enantiomerically enriched α-chiral esters with essentially no loss of stereochemical integrity.
