37348-16-6

Basic information

• Product Name: HYDROBROMIC ACID >33% IN ACETIC ACID
• Synonyms: HYDROBROMIC ACID >33% IN ACETIC ACID;Hydrogen bromide [33 wt% solution in glacial acetic acid];Hydrogen bromide, 33 wt.% solution in glacial acid, AcroSeal, pure;Hydrogen broMide, pure, 33 wt.% solution in glacial acid, AcroSeal;Acetic acid, mixt. with hydrobromic acid;Hydrogen bromide, 33 wt.% solution in acetic acid, extra pure
• CAS NO: 37348-16-6
• Molecular Formula: BrH*2C₂H₄O₂
• Molecular Weight: 80.91194
• Mol File: 37348-16-6.mol
• Article Data: 0

Chemical Properties

• Flash Point: 65 °C
• Appearance: /
• Density: 1.40 g/mL at 20 °C(lit.)
• Water Solubility: Miscible with water, alcohol and organic solvents.
• CAS DataBase Reference: HYDROBROMIC ACID >33% IN ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: HYDROBROMIC ACID >33% IN ACETIC ACID(37348-16-6)
• EPA Substance Registry System: HYDROBROMIC ACID >33% IN ACETIC ACID(37348-16-6)

Safety Data

• Hazard Codes: C
• Statements: 35-37
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 1
• Hazardous Substances Data: 37348-16-6(Hazardous Substances Data)

Usage

Chemical Properties

Hydrobromic acid is a Clear yellow to golden colored fuming liquid. It is a strong acid formed by dissolving the diatomic molecule hydrogen bromide (HBr) in water.

Uses

Hydrobromic acid is an indispensable raw material for organic intermediates, inorganic pharmaceuticals, photosensitive materials, dyes and medicines. It is also used in the production of bromine compounds. It is used as an important agent in the industrial processes of isomerization, polymerization, hydration and dehydration and esterification reactions. It plays an essential role for the extraction of mercury from the cinnebar ore.

Reactions

Hydrobromic acid reacts with sulfuric acid forming sulfur dioxide, bromine and water. The chemical equation is given below.2HBr + H2SO4 → Br2 + SO2 + 2H2OHydrobromic acid reacts with propene undergoe addition reaction resulting in the formation of 2-Bromopropane. The chemical equation is given below.HBr + C3H6 → C3H7Br

Synthetic route

1-(9',10'-dihydroxydecyl)-3,7-dimethylxanthine (156918-13-7) + acetic acid hydrobromide (37348-16-6) → 1-(9'-acetoxy-10'-bromodecyl)-3,7-dimethylxanthine

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane; water	100%

3-(8,9-dihydroxynonyl)-1-methyluracil (156918-28-4) + acetic acid hydrobromide (37348-16-6) → 3-(8-acetoxy-9-bromononyl)-1-methyluracil (159431-55-7)

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane; water	97%

1-(5,6-dihydroxyhexyl)-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione (38975-41-6) + acetic acid hydrobromide (37348-16-6) → 1-(5-acetoxy-6-bromohexyl)-3,7-dimethylxanthine

Conditions	Yield
With sodium hydrogencarbonate In (2S)-N-methyl-1-phenylpropan-2-amine hydrate	96%
With sodium hydrogencarbonate In (2S)-N-methyl-1-phenylpropan-2-amine hydrate	96%
With sodium hydrogencarbonate In (2S)-N-methyl-1-phenylpropan-2-amine hydrate	96%
With sodium hydrogencarbonate In (2S)-N-methyl-1-phenylpropan-2-amine hydrate	96%
With sodium hydrogencarbonate In (2S)-N-methyl-1-phenylpropan-2-amine hydrate	96%

1-(7,8-dihydroxyoctyl)-3,7-dimethylxanthine + acetic acid hydrobromide (37348-16-6) → 1-(7-acetoxy-8-bromooctyl)3,7-dimethylxanthine (159431-48-8)

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane; water	94%

ethyl 1,3-dimethylpyrazole-5-carboxylate (5744-40-1) + acetic acid hydrobromide (37348-16-6) → ethyl 4-bromomethyl-1,3-dimethylpyrazole-5-ylcarboxylate (166313-49-1)

Conditions	Yield
With paraformaldehyde	86.3%

3-(8,9-dihydroxynonyl)-1-methylthymine (156918-35-3) + acetic acid hydrobromide (37348-16-6) → 3-(8-acetoxy-9-bromononyl)-1-methylthymine (159431-56-8)

Conditions	Yield
With sodium hydrogencarbonate In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane; water	85%

1-benzyl-4-(benzyloxy-carbonylamino methyl)-5-(phthalimidoacetyl)-1,3,4,5-tetrahydro-1,5-benzodiazepin-2(2H)-one + acetic acid hydrobromide (37348-16-6) → 4-(Aminomethyl)-1-benzyl-5-(phthalimidoacetyl)-1,3,4,5-tetrahydro-1,5-benzodiazepin-2(2H)-one hydrobromide

Conditions	Yield
In chloroform	82%

acetic acid hydrobromide (37348-16-6) → acetic acid (64-19-7) + HBr

Conditions	Yield
In various solvent(s) at -125.1 - -120.1℃; Kinetics;

(S)-4-(benzyloxycarbonylamino)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiochromane-7-carboxamide (361370-30-1) + acetic acid hydrobromide (37348-16-6) → (S)-4-amino-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiochromane-7-carboxamide 2HBr

Conditions	Yield
In ethyl acetate

4-n-octylacetophenone (10541-56-7) + acetic acid hydrobromide (37348-16-6) → α-bromomethyl p(n-octyl)phenyl cetone (64068-76-4)

Conditions	Yield
With bromine In acetic acid

7-[1-(2,6-dimethylpyridin-4-yl)-4-ethoxycarbonylpiperidin-4-ylmethoxy]-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester (247132-48-5) + 1H-pyrazole-1-carboximidamide hydrochloride (4023-02-3) + acetic acid hydrobromide (37348-16-6) → 4-(2-amidino-1,2,3,4-tetrahydroisoquinolin-7-yloxymethyl)-1-(2,6-dimethylpyridin-4-yl)piperidine-4-carboxylic acid ethyl ester dihydrochloride

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N-methyl-acetamide; di-isopropyl ether

N-(pyridin-4-yl)-2-benzyloxy-4-benzyloxycarbonylaminomethylbenzamide + hydrochloric acid-methanol + acetic acid hydrobromide (37348-16-6) → N-(pyridin-4-yl)-4-aminomethyl-2-benzyloxybenzamide monohydrochloride monohydrate

Conditions	Yield
With sodium hydroxide; acetic acid In ethyl acetate

(R)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-3-azido-4-(1-benzyloxycarbonylaminoethyl)benzamide (173898-06-1) + acetic acid hydrobromide (37348-16-6) → (R)-(-)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)-3-azidobenzamide dihydrobromide

4'-Benzyloxy-3'-(2-benzyloxyethyl)acetophenone + acetic acid hydrobromide (37348-16-6) → 4'-benzyloxy-3'-(2-benzyloxyethyl)-2-bromoacetophenone

Conditions	Yield
With bromine In chloroform
With bromine In chloroform

4-benzyloxycarbonyl-5-{2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)-(L)-phenylalanyl]aminoethyl}thiazole + acetic acid hydrobromide (37348-16-6) → 4-carboxy-5-{2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)-(L)-phenylalanyl]aminoethyl}thiazole

2-butyrylamino-5-[4,5-dihydropyridazin-3(2H)-on-6-yl]indane (166978-79-6) + acetic acid hydrobromide (37348-16-6) → 2-butyrylamino-5-[pyridazin-3(2H)-on-6-yl]indane (166979-16-4)

Conditions	Yield
With dimethyl sulfoxide In acetic acid

2-(butyrylamino)methyl-5-[4,5-dihydropyridazin-3(2H)-on-6-yl]indane (166978-80-9) + acetic acid hydrobromide (37348-16-6) → 2-(butyrylamino)methyl-5-[pyridazin-3(2H)-on-6-yl]indane (166979-30-2)

Conditions	Yield
With dimethyl sulfoxide In di-isopropyl ether; acetic acid

6-[4-(4-aminobutyl)phenyl]-4,5-dihydropyridazin-3(2H)-one (186651-94-5) + di-isopropyl ether (108-20-3) + acetic acid hydrobromide (37348-16-6) → 6-[4-(4-aminobutyl)phenyl]pyridazin-3(2H)-one hydrobromide (186652-06-2)

Conditions	Yield
In acetic acid; dimethyl sulfoxide

2-(propylsulfonylaminomethyl)-5-[4,5-dihydropyridazin-3(2H)-on-6-yl]indane (166183-48-8) + di-isopropyl ether (108-20-3) + acetic acid hydrobromide (37348-16-6) → 2-(propylsulfonylaminomethyl)-5-[pyridazin-3(2H)-on-6-yl]indane (166183-09-1)

Conditions	Yield
With dimethyl sulfoxide In acetic acid
With dimethyl sulfoxide In acetic acid

5-(3-ethoxypropyl)-4,5-dihydro-1-methyl[1,2,4]triazolo[4,3-a]quinoxaline (149669-04-5) + acetic acid hydrobromide (37348-16-6) → 5-(3-bromopropyl)-4,5-dihydro-1-methyl[1,2,4]triazolo [4,3-a]quinoxaline (149669-05-6)

Conditions	Yield
With sodium hydroxide

6-[4-(4-(pyridin-3-ylcarbonylamino)butyl)phenyl]-4,5-dihydropyridazin-3(2H)-one (186652-51-7) + acetic acid hydrobromide (37348-16-6) → 6-[4-(4-(pyridin-3-ylcarbonylamino)butyl)phenyl]pyridazin-3(2H)-one (186652-17-5)

Conditions	Yield
In hydrated ethanol; ethanol; di-isopropyl ether; acetic acid; dimethyl sulfoxide

6-[4-(4-aminobutyl)phenyl]-4,5-dihydro-4,5-dimethylpyridazin-3(2H)-one (186652-99-3) + acetic acid hydrobromide (37348-16-6) → 6-[4-(4-aminobutyl)phenyl]-4,5-dimethylpyridazin-3(2H)-one (186652-64-2)

Conditions	Yield
With acetic acid In water; dimethyl sulfoxide

3(R)-(5-benzyloxycarbonyl-amino-1-carboxypentyl)amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid + diethyl ether (60-29-7) + acetic acid hydrobromide (37348-16-6) → 3(R)-(5-amino-1-carboxypentyl)amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid dihydrobromide

Conditions	Yield
In acetic acid; Petroleum ether
In acetic acid; Petroleum ether

acetic acid hydrobromide (37348-16-6) + 6-[2-(7-methylimidazo[1,2-a]pyridin-2-yl)ethyl]-2-aminobenzothiazole (128616-71-7) → 6-[2-(3-Bromo-7-methylimidazo[1,2-a]pyridin-2-yl)ethyl]-2-aminobenzothiazol

Conditions	Yield
With pyridinium hydrobromide perbromide In diethyl ether; water; acetic acid; ethyl acetate

(-)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(N-benzyloxycarbonyl-N-methylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one + acetic acid hydrobromide (37348-16-6) → (-)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(N-methylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one (100892-81-7)

Conditions	Yield
In water; benzene

chloroformethanol + (-)-cis-2-(4-methoxyphenyl)-3-n-butyryloxy-5-[2-(N-benzyloxycarbonyl-N-methylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one + acetic acid hydrobromide (37348-16-6) → (-)-cis-2-(4-methoxyphenyl)-3-n-butyryloxy-5-[2-(N-methylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Conditions	Yield
With acetic acid In ice-water

(-)-cis-2-(4-methoxyphenyl)-3-propionyloxy-5-[2-(N-benzyloxycarbonyl-N-methylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one + acetic acid hydrobromide (37348-16-6) → (-)-cis-2-(4-methoxyphenyl)-3-propionyloxy-5-[2-(N-methylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Conditions	Yield
In water; benzene

ethyl 2-methylamino-5-propionyl-4-thiazolecarboxylate + acetic acid hydrobromide (37348-16-6) → ethyl 2-methylamino-5-(2-bromopropionyl)-4-thiazolecarboxylate (94284-85-2)

Conditions	Yield
With pyridinium hydrobromide perbromide In acetic acid

diethyl ether (60-29-7) + tert-butyl 3(R)-[6-(1-benzyloxycarbonyl-4-piperidyl)-1(S)-ethoxycarbonylhexyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetate (100303-32-0) + acetic acid hydrobromide (37348-16-6) → 3(R)-[1(S)-carboxy-6-(4-piperidyl)hexyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepine-5-acetic acid (100277-63-2)

Conditions	Yield
In sodium hydroxide; acetic acid

N-[N-[(S)-5-(4-piperidyl)-1-ethoxycarbonylpentyl]-L-alanyl]-N-(indan-2-yl)glycine tert-butyl ester + diethyl ether (60-29-7) + acetic acid hydrobromide (37348-16-6) → N--L-alanyl>-N-(2-inadanyl)glycine dihydrobromide

Conditions	Yield
In acetic acid

Upstream product

• 64-19-7 acetic acid 

Downstream Products

• 64194-92-9 2-[3-(acetylamino-methyl)-5-chloromethyl-[1,2,4]triazol-4-yl]-5-chloro-benzophenone 
• 65699-26-5 2',5-dichloro-2-(3-dimethylcarbamoyl-5-aminomethyl-1H-1,2,4-triazol-1-yl)benzophenone hydrobromide 
• 64194-87-2 glycine [4-(2-benzoyl-4-chloro-phenyl)-4H-[1,2,4]triazol-3-ylmethyl]-amide 
• 166313-49-1 ethyl 4-bromomethyl-1,3-dimethylpyrazole-5-ylcarboxylate 
• 100892-81-7 (-)-cis-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(N-methylamino)ethyl]-8-chloro-2,3-dihydro-1,5-benzothiazepin-4(5H)-one 
• 64068-76-4 α-bromomethyl p(n-octyl)phenyl cetone 
• 186652-64-2 6-[4-(4-aminobutyl)phenyl]-4,5-dimethylpyridazin-3(2H)-one 
• 186652-17-5 6-[4-(4-(pyridin-3-ylcarbonylamino)butyl)phenyl]pyridazin-3(2H)-one 
• 186652-06-2 6-[4-(4-aminobutyl)phenyl]pyridazin-3(2H)-one hydrobromide