373641-40-8

Basic information

• Product Name: ethyl N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamate
• Synonyms: ethyl N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamate
• CAS NO: 373641-40-8
• Molecular Weight: 460.742
• Mol File: 373641-40-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamate(373641-40-8)
• EPA Substance Registry System: ethyl N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamate(373641-40-8)

Safety Data

• Hazardous Substances Data: 373641-40-8(Hazardous Substances Data)

Upstream product

• 933-75-5 2,3,6-trichlorophenol 
• 88-69-7 2-(1-methylethyl)phenol 
• 373643-21-1 ethyl n-[4-(4-benzyloxy-3-isopropylphenoxy)-2,3,5-trichlorophenyl]malonamate 
• 373642-94-5 4-(4-benzyloxy-3-isopropylphenoxy)-2,3,5-trichlorophenylamine 

Downstream Products

• 373641-60-2 N-[2,3,5-trichloro-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamic acid 

Relevant articles and documents

Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia

Thyromimetics that specifically target TRβ have been shown to reduce plasma cholesterol levels and avoid atherosclerosis through the promotion of reverse cholesterol transport in an animal model. We designed novel thyromimetics with high receptor (TRβ) and organ (liver) selectivity based on the structure of eprotirome (3) and molecular modeling. We found that indane derivatives are potent and dual-selective thyromimetics expected to avoid hypothyroidism in some tissues as well as heart toxicity. KTA-439 (29), a representative indane derivative, showed the same high human TRβ selectivity in a binding assay as 3 and higher liver selectivity than 3 in a cholesterol-fed rat model.