37421-04-8

Basic information

• Product Name: n-methyl-2-phenoxy-ethylamin
• Synonyms: alpha-phenoxy-beta-methylaminoethane;n-methyl-2-phenoxy-ethanamin;n-methyl-2-phenoxy-ethylamin;N-methyl-2-phenoxyethanamine(SALTDATA: FREE);methyl-(2-phenoxyethyl)amine hydrochloride;N-methyl-2-phenoxyethanamine hydrochloride;N-methyl-2-phenoxy-ethanamine hydrochloride
• CAS NO: 37421-04-8
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.20562
• Mol File: 37421-04-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 236.4°C at 760 mmHg
• Flash Point: 90.7°C
• Appearance: /
• Density: 0.973±0.06 g/cm3(Predicted)
• Vapor Pressure: 0.0474mmHg at 25°C
• PKA: 9.23±0.10(Predicted)
• CAS DataBase Reference: n-methyl-2-phenoxy-ethylamin(CAS DataBase Reference)
• NIST Chemistry Reference: n-methyl-2-phenoxy-ethylamin(37421-04-8)
• EPA Substance Registry System: n-methyl-2-phenoxy-ethylamin(37421-04-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• WGK Germany: 3
• RTECS: KR9239990
• HazardClass: 8
• Hazardous Substances Data: 37421-04-8(Hazardous Substances Data)

Usage

General Description

N-methyl-2-phenoxy-ethylamine is a chemical compound with the molecular formula C10H15NO. It is an organic compound that contains a methyl group and a phenoxy group attached to an ethylamine backbone. n-methyl-2-phenoxy-ethylamin is commonly used in the synthesis of pharmaceuticals and other organic compounds, as well as in research and development of new materials. It has the potential to exhibit a range of chemical and biological properties, depending on its specific structure and functional groups. N-methyl-2-phenoxy-ethylamine is thus a versatile and important chemical intermediate in many industrial and scientific applications.

InChI:InChI=1/C9H13NO/c1-10-7-8-11-9-5-3-2-4-6-9/h2-6,10H,7-8H2,1H3/p+1

Upstream product

• 589-10-6 phenoxyethyl bromide 
• 74-89-5 methylamine 
• 108-95-2 phenol 
• 122-99-6 2-Phenoxyethanol 
• 58929-71-8 Benzyl-methyl-(2-phenoxy-ethyl)-amine 
• 15422-25-0 N-methyl-2-phenoxyacetamide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 101114-25-4 3-methyl-crotonic acid-[methyl-(2-phenoxy-ethyl)-amide] 
• 93-90-3 N-(2-hydroxyethyl)-N-methylaminobenzene 
• 313654-76-1 3-Chloro-N-methyl-N-(2-phenoxyethyl)-2-pyrazinamine 
• 1178972-91-2 C₁₉H₂₁N₅O₃ 
• 122-98-5 2-Anilinoethanol 
• 708-05-4 4-methyl-6,7-benzo-1-ox-4-azepin-5-one 
• 102226-84-6 N-[3-(7,8-Dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-on-3-yl)-propyl]-N-(2-phenyloxyethyl)-methylamine 
• 58929-64-9 Methyl-[2-(3-{2-[methyl-(2-phenoxy-ethyl)-amino]-ethoxy}-phenoxy)-ethyl]-(2-phenoxy-ethyl)-amine 
• 58929-62-7 Methyl-[2-(4-{2-[methyl-(2-phenoxy-ethyl)-amino]-ethoxy}-butoxy)-ethyl]-(2-phenoxy-ethyl)-amine 
• 58929-50-3 Methyl-[2-(2-{2-[methyl-(2-phenoxy-ethyl)-amino]-ethoxy}-ethoxy)-ethyl]-(2-phenoxy-ethyl)-amine 

Relevant articles and documents

2-(1-naphthyloxy)ethylamines with enhanced affinity for human 5-HT(1Dβ) (h5-HT(1B)) serotonin receptors

Although the β-adrenergic antagonist propanolol (1) binds at rodent 5- HT(1B) serotonin receptors, it displays low affinity (K(i) > 10 000 nM) for its species homologue 5-HT(1DB) (i.e., h5-HT(1B)) receptors. The structure of propanolol was systematically modified in an attempt to enhance its affinity for the latter population of receptors. Removal of the alkyl hydroxyl group, shortening of the O-alkyl chain from three to two methylene groups, and variation of the terminal amine substituent resulted in compounds, such as N- monomethyl-2-(1-naphthyloxy)-ethylamine (11; K(i) = 26 nM), that display significantly higher h5-HT(1B) affinity than propanolol. Compound 11 was shown to bind equally well at human 5-HT(1Dα) (h5-HT(1D) receptors (K(i) = 34 nM) and was further demonstrated to possess h5-HT(1B) agonist character in an adenylate cyclase assay. It would appear that such (aryloxy)alkylamines may represent a novel class of 5-HT(1D) receptor agonists.