374675-64-6

Basic information

• Product Name: P-TOLYL ISOCYANATE
• Synonyms: ISOCYANIC ACID P-TOLYL ESTER;4-TOLYL ISOCYANATE;P-METHYL PHENYL ISOCYANATE;4-METHYLPHENYLSISOCYANATE;Isoyanic acid P-tolyl ester
• CAS NO: 374675-64-6
• Molecular Formula: C8H7NO
• Molecular Weight: 133.15
• EINECS: 210-743-4
• Mol File: 374675-64-6.mol
• Article Data: 98

Chemical Properties

• Boiling Point: 70-72 °C10 mm Hg(lit.)
• Flash Point: 152 °F
• Appearance: /
• Density: 1.056 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.531(lit.)
• Storage Temp.: 0-6°C
• CAS DataBase Reference: P-TOLYL ISOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: P-TOLYL ISOCYANATE(374675-64-6)
• EPA Substance Registry System: P-TOLYL ISOCYANATE(374675-64-6)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-42
• Safety Statements: 23-26-45
• WGK Germany: 3
• RTECS: DA3681666
• F: 21
• Hazardous Substances Data: 374675-64-6(Hazardous Substances Data)

Usage

General Description

P-Tolyl isocyanate is a chemical compound with the formula C8H7NO, consisting of a tolyl group attached to an isocyanate functional group. It is used in the production of polyurethane foams, coatings, and adhesives. P-Tolyl isocyanate is a highly reactive compound and can cause skin and respiratory irritation upon exposure. It is important to handle this chemical with care, using appropriate protective equipment and following safety protocols to minimize the risk of adverse health effects. Additionally, proper storage and handling procedures should be followed to prevent accidental release or exposure to this chemical.

Upstream product

• 622-51-5 p-tolylurea 
• 920-66-1 1,1,1,3',3',3'-hexafluoro-propanol 
• 197569-70-3 N-1-adamantyl-N-p-tolylcarbamoyl chloride 
• 75-79-6 Methyltrichlorosilane 
• 5602-96-0 methyl p-tolylcarbamate 
• 134295-27-5 3-Benzoyl-2,8,8-triphenyl-1,6-di-p-tolyl-1,6-diaza-spiro[3.4]oct-2-ene-5,7-dione 
• 132931-81-8 3,3-Dibenzyl-1-(4-tolyl)-1-nitrosourea 
• 132931-83-0 3-Benzyl-3-methyl-1-(4-tolyl)-1-nitrosourea 
• 5308-12-3 O-ethyl N-(4-methylphenyl)thiocarbamate 
• 42868-89-3 2-oxo-2-(p-tolylamino)acetic acid 
• 7160-01-2 N,N-dimethyl-N'-(4-tolyl)urea 
• 22693-32-9 4-methylbenzoyl azide 
• 201230-82-2 carbon monoxide 
• 99-99-0 1-methyl-4-nitrobenzene 

Downstream Products

• 6849-99-6 5-p-tolylcarbamoyloxy-benzo[1,3]dioxole 
• 81416-22-0 (3aS,7aS)-3-p-Tolyl-3a,7a-dihydro-3H-oxazolo[4,5-b]pyridin-2-one 
• 1785-03-1 1,3,5-tris(4-methylphenyl)-1,3,5-triazinane-2,4,6-trione 
• 160060-64-0 N,N'-Di-p-tolyl-5H-4b,10,11-triaza-benzo[b]fluorene-10-carboxamidine 
• 115483-91-5 2,7a,9,10-Tetrahydro-9,9-dimethyl-3-(4-methylanilino)-2-(4-methylphenyl)-1-oxo-1H-furo<3,2-e>chinazolin-6,7-dicarbonitril 
• 87685-04-9 4-(N,O-bis(4-tolylcarbamoyl)hydroxylamino)-1-(4-tolylcarbamoyloxy)-3-(3-chlorophenyl)-5,5-dimethylimidazolidin-2-one 
• 80820-83-3 3-Methyl-1-phenyl-5-(4-tolyl)biuret 

Relevant articles and documents

Homogeneous catalytic carbonylation of nitroaromatics. 8. Kinetic and mechanistic studies of the carbon-nitrogen bond and product forming steps from Ru(Ph2PCH2CH2PPh2)(CO) 2[C(O)OCH3]2: The turnover limiting reactions in the catalytic cycle

Mechanistic studies of the reaction of (OC-6-32)-dicarbonylbis(methoxycarbonyl)[1,2-bis(diphenylphosphino)-ethane] ruthenium(II) with p-toluidine to form N,N'-di-p-tolylurea are presented. The overall reaction was studied from 22 to 103°C and was found to be first order with respect to each reactant. Spectroscopic and kinetic studies between 22 and 52°C showed that the reaction proceeds through a species, Ru(dppe)(CO)2[C(O)OCH3] [C(O)-NH(p-tolyl)], which is in equilibrium with Ru(dppe)(CO)2[C(O)OCH3]2. The mechanism of the C-N bond forming step is proposed to involve nucleophilic attack on a coordinated Ru-CO moiety with subsequent cleavage of the C(O)-OMe bond. The methoxycarbonyl-carbamoyl complex decomposes in a unimolecular fashion to liberate CH3OH, the starting catalyst Ru(dppe)(CO)3, and p-tolyl isocyanate, which is immediately scavenged by excess amine to form N,N'-di-p-tolylurea. Studies of the analogous bis(isopropylcarbamoyl) complex provided supporting evidence for isocyanate elimination. Thermolysis of (OC-6-32)-dicarbonylbis(isopropylcarbamoyl)[1,2-bis(diphenylphosphino)-ethane] ruthenium(II) yields isopropylamine, the starting catalyst Ru(dppe)(CO)3, and isopropyl isocyanate, which reacts with isopropylamine over time to form diisopropylurea. The kinetics obtained from all of the stoichiometric reactions were combined into a suitable expression and found to lie on the same Arrhenius activation energy plot as the overall rate of the catalytic reaction.

Insecticidal sterilization composition and application thereof

The insecticidal sterilization composition comprises the following raw materials in parts by weight 1 - 50% parts of isopyrazam, 1 - 40% parts of trichloroisocyanuric acid, 1 - 2% parts of synergist and the balance of excipients. By compounding isothiopham and trichloroisocyanuric acid, the effects are complementary, the bactericidal spectrum is wider, and the bactericidal activity is high. Under the action of the initiator A I BN, the intermediate 5, the intermediate 6 and the acrylamide are polymerized to obtain a synergist which is a water-soluble compound and is grafted with a hindered amine structure, a benzophenone structure and a benzisothiazolinone structure.

Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure

Formyl peptide receptor 2 (FPR2) agonists can stimulate resolution of inflammation and may have utility for treatment of diseases caused by chronic inflammation, including heart failure. We report the discovery of a potent and selective FPR2 agonist and its evaluation in a mouse heart failure model. A simple linear urea with moderate agonist activity served as the starting point for optimization. Introduction of a pyrrolidinone core accessed a rigid conformation that produced potent FPR2 and FPR1 agonists. Optimization of lactam substituents led to the discovery of the FPR2 selective agonist 13c, BMS-986235/LAR-1219. In cellular assays 13c inhibited neutrophil chemotaxis and stimulated macrophage phagocytosis, key end points to promote resolution of inflammation. Cardiac structure and functional improvements were observed in a mouse heart failure model following treatment with BMS-986235/LAR-1219.