3749-36-8

Basic information

• Product Name: 3,4-Dihydro-2H-pyran-2-methanol
• Synonyms: DHP LINKER;2H-PYRAN-2-METHANOL, 3,4-DIHYDRO-;2-HYDROXYMETHYL-3,4-DIHYDRO-2H-PYRAN;3,4-DIHYDRO-2H-PYRAN-2-METHANOL;3,4-DIHYDRO-2H-PYRAN-2-YLMETHANOL;3,4-DIHYDRO-2H-PYRANE-2-METHANOL;3,4-Dihydroxy-2H-pyran-2-Methanol;2-HYDROXYMETHYL-3,4-DIHYDRO-2H-PRYAN(DHP-LINKER)
• CAS NO: 3749-36-8
• Molecular Formula: C₆H₁₀O₂
• Molecular Weight: 114.14
• EINECS: 250-545-5
• Product Categories: Miscellaneous;Alkohols;Linkers for Solid Phase Synthesis;Linkers for solid phase synthesis
• Mol File: 3749-36-8.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 92-93 °C25 mm Hg(lit.)
• Flash Point: 85°C
• Appearance: /
• Density: 1.101 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0697mmHg at 25°C
• Refractive Index: n20/D 1.478(lit.)
• Storage Temp.: 2-8°C
• PKA: 14.34±0.10(Predicted)
• BRN: 107275
• CAS DataBase Reference: 3,4-Dihydro-2H-pyran-2-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dihydro-2H-pyran-2-methanol(3749-36-8)
• EPA Substance Registry System: 3,4-Dihydro-2H-pyran-2-methanol(3749-36-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-37/39
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 3749-36-8(Hazardous Substances Data)

Usage

Chemical Properties

liquid

Uses

Different sources of media describe the Uses of 3749-36-8 differently. You can refer to the following data:
1. Preparation of supported dihydropyran for mild immobilization and cleavage of alcohols
2. It is used in the preparation of supported dihydropyran for mild immobilization and cleavage of alcohols

InChI:InChI=1/C6H10O2/c7-5-6-3-1-2-4-8-6/h2,4,6-7H,1,3,5H2

Upstream product

• 16698-52-5 3,4-dihydro-2H-pyran-2-carboxylic acid sodium salt 
• 3540-36-1 (3,4-dihydro-2H-pyran-2-yl)methyl 3,4-dihydro-2H-pyran-2-carboxylate 
• 74-88-4 methyl iodide 
• 20583-51-1 1SR,5SR-6,8-dioxabicyclo<3.2.1>oct-3-ene 
• 83568-11-0 racem. ethyl 3,4-dihydro-2H-pyran-2-carboxylate 
• 100-73-2 acrolein dimer 

Downstream Products

• 106-69-4 hexane-1,2,6-triol 
• 124654-38-2 cis-methyl 6-<(tert-butyldiphenylsilyloxy)methyl>tetrahydro-α,α-dimethyl-2H-pyran-2-acetate 
• 124654-38-2 trans-methyl 6-<(tert-butyldiphenylsilyloxy)methyl>tetrahydro-α,α-dimethyl-2H-pyran-2-acetate 
• 124654-49-5 trans-2-(benzenesulphonyl)-6-<(tert-butyldiphenylsilyloxy)methyl>tetrahydro-2H-pyran 
• 7007-32-1 (3,4-Dihydro-2H-pyran-2-yl)methyl 4-Methylbenzenesulfonate 
• 858665-29-9 C₂₀H₂₀F₃NO₂ 
• 858665-31-3 C₂₀H₂₀F₃NO₂ 
• 1219814-88-6 C₂₀H₂₀F₃NO₃ 
• 1219814-90-0 C₂₂H₂₇NO₂ 
• 1219814-92-2 C₁₉H₁₉ClFNO₂ 
• 1219814-91-1 C₁₉H₁₉BrFNO₂ 

Relevant articles and documents

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Towards a library of chromene cannabinoids: A combinatorial approach on solid supports

A novel solid-phase synthesis towards classical cannabinoids is presented. Starting from immobilized salicylaldehydes the desired THC-analogous tricycles are obtained in four atom-economic steps including cleavage. The reagents of the employed reactions (domino oxa-Michael-aldol, Wittig, and Diels-Alder) can be varied easily, providing the basis for a combinatorial approach. Overall yields range from 20-60%. Georg Thieme Verlag Stuttgart New York.

Efficient polymer-assisted strategy for the deprotection of protected oligosaccharides

(Chemical Equation Presented) New strategies in sugar synthesis: A prelinker containing a dihydropyranyl moiety and an activated ester can be attached to a sugar, which is then loaded onto an amino-modified support by amidation. Standard protecting-group manipulations are possible. Final cleavage of the linker under mildly acidic conditions provides the fully deprotected oligosaccharides. TFA=trifluoroacetic acid.