37517-81-0Relevant articles and documents
Enantioselective α-Amination of Acyclic 1,3-Dicarbonyls Catalyzed by N-Heterocyclic Carbene
Santra, Surojit,Maji, Ujjwal,Guin, Joyram
supporting information, p. 468 - 473 (2020/02/04)
Herein, we describe a method for the catalytic enantioselective α-amination of α-substituted acyclic 1,3-ketoamides and 1,3-amidoesters that affords the products possessing N-substituted quaternary stereocenters with a chiral N-heterocyclic carbene (NHC). The reaction is based on the utilization of an intrinsic Br?nsted base characteristic of NHC that enables the catalytic formation of a chiral ion pair comprising the enolate and the azolium ion. A series of challenging open-chain α-substituted 1,3-dicarbonyls are aminated via this method with ee's of ≤99%.
Compound for promoting apoptosis of cancer cells, pharmaceutical composition containing the same and uses thereof
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Paragraph 0054; 0055; 0056, (2016/10/09)
The present invention provides a compound of a formula (I) and a salt thereof, wherein m is an integer of 2 to 7, and R is independently at least one selected from the group consisting of hydrogen and C1-C20 alkyl. The compound promotes apoptosis in cancer cells and inhibits growth of the cancer cells. The present invention also provides a pharmaceutical composition which comprises the compound of the formula (I), a salt thereof and a pharmaceutically acceptable carrier. The present invention further provides uses of the compound of the formula (I) or the salt thereof in preparation of medicine for treating cancer.
trans-directing ability of amide groups in cyclopropanation: Application to the asymmetric cyclopropanation of alkenes with diazo reagents bearing two carboxy groups
Marcoux, David,Charette, Andre B.
supporting information; experimental part, p. 10155 - 10158 (2009/05/30)
(Chemical Equation Presented) Highly stereoselective: A highly enantioselective (up to 97 % ee) and diastereoselective (>30:1 d.r.) Rh II-catalyzed cyclopropanation of alkenes using a diazo reagent bearing two carboxy groups is described. This new methodology exploits the powerful trans-directing ability of amides to improve enantiocontrol. Mono- and disubstituted olefins are cyclopropanated in good yields. nttl=N-1,8-naphthoyl- tert-leucine.