37536-32-6

Basic information

• Product Name: Benzoic acid, 2-hydroxy-, 2-[(phenylamino)thioxomethyl]hydrazide
• CAS NO: 37536-32-6
• Molecular Formula: C14H13N3O2S
• Molecular Weight: 287.342
• Mol File: 37536-32-6.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-hydroxy-, 2-[(phenylamino)thioxomethyl]hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-hydroxy-, 2-[(phenylamino)thioxomethyl]hydrazide(37536-32-6)
• EPA Substance Registry System: Benzoic acid, 2-hydroxy-, 2-[(phenylamino)thioxomethyl]hydrazide(37536-32-6)

Safety Data

• Hazardous Substances Data: 37536-32-6(Hazardous Substances Data)

Upstream product

• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 1441-87-8 salicyloyl chloride 
• 119-36-8 methyl salicylate 
• 69-72-7 salicylic acid 
• 103-72-0 phenyl isothiocyanate 
• 936-02-7 2-Hydroxybenzoylhydrazine 

Downstream Products

• 81518-26-5 5-(2-hydroxyphenyl)-4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione 
• 94507-86-5 2-(5-(phenylamino)-1,3,4-oxadiazol-yl)phenol 
• 81518-33-4 2-(5-Methylsulfanyl-4-phenyl-4H-[1,2,4]triazol-3-yl)-phenol 
• 81518-35-6 2-(5-Allylsulfanyl-4-phenyl-4H-[1,2,4]triazol-3-yl)-phenol 
• 81518-34-5 2-(5-Ethylsulfanyl-4-phenyl-4H-[1,2,4]triazol-3-yl)-phenol 
• 81518-36-7 2-(4-Phenyl-5-propylsulfanyl-4H-[1,2,4]triazol-3-yl)-phenol 
• 81518-37-8 2-(5-Butylsulfanyl-4-phenyl-4H-[1,2,4]triazol-3-yl)-phenol 
• 135815-44-0 Pd(C₆H₅NHCSNHNHCOC₆H₄-o-OH)Cl₂ 
• 122448-07-1 bis-[5-(2-hydroxy-phenyl)-4-phenyl-4H-[1,2,4]triazol-3-yl]-disulfide 

Relevant articles and documents

Pharmacomodulations of the benzoyl-thiosemicarbazide scaffold reveal antimicrobial agents targeting D-alanyl-D-alanine ligase in bacterio

D-Alanyl-D-alanine ligase (Ddl) is a validated and attractive target among the bacterial enzymes involved in peptidoglycan biosynthesis. In the present work, we investigated the pharmacomodulations of the benzoylthiosemicarbazide scaffold to identify new Ddl inhibitors with antibacterial potency. Five novel series of thiosemicarbazide analogues, 1,2,4-thiotriazole-3-thiones, 1,3,4-thiadiazoles, phenylthiosemicarbazones, diacylthiosemicarbazides and thioureas were synthesized via straightforward procedures, then tested against Ddl and on susceptible or resistant bacterial strains. Among these, the thiosemicarbazone and thiotriazole were identified as the most promising scaffolds with Ddl inhibition potency in the micromolar range. Antimicrobial evaluation of salicylaldehyde-4(N)-(3,4-dichlorophenyl) thiosemicarbazone 33, one of the best compounds in our study, revealed interesting antimicrobial activities with values of 3.12–6.25 μM (1.06–2.12 μg/mL) against VRE strains and 12.5–25.0 μM (4.25–8.50 μg/mL) towards MRSA and VRSA strains. A detailed mechanistic study was conducted on the Ddl inhibitors 4-(3,4-dichlorophenyl)-5-(2-hydroxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione 20 and compound 33, and revealed a bactericidal effect at 5 × MIC concentration after 7 h and 24 h, respectively, and a bacteriostatic effect at 1 × MIC or 2 × MIC without any sign of bacterial membrane disruption at these lower concentrations. Finally, 20 and 33 were proved to target Ddl in bacterio via intracellular LC-MS dosage of D-Ala, L-Ala and D-Ala-D-Ala. Although, at this stage, our results indicate that other mechanisms might be involved to explain the antimicrobial potency of our compounds, their ability to inhibit the growth of strains resistant to usual antibiotics, as well as strains that express alternative ligases, sets the stage for the development of new antimicrobial agents potentially less sensitive to resistance mechanisms.

Design, Synthesis and Antibacterial Evaluation of 1-[(1R,2S)-2-Fluorocyclopropyl]ciprofloxacin-1,2,4-triazole-5(4H)-thione Hybrids

A new class of 1-[(1R,2S)-2-fluorocyclopropyl]ciprofloxacin (CPFX)-1,2,4-triazole-5(4H)-thione hybrids 6a?–?6o was designed, synthesized and evaluated for their in?vitro antibacterial activities against a panel of clinically important drug-sensitive and d

Synthesis of a series of novel tetra-tert-butylcalix[4]arene linked to 1,2,4-triazole and 1,3,4-oxadiazole derivatives

A series of tetra-tert-butylcalix[4]arene linked to 1,2,4-triazole-5-thiones and 1,3,4-oxadiazole-5-thiones derivatives at lower rim were synthesized by the reaction of 1,2,4-triazole-5-thione and 1,3,4-oxadiazole-5-thione with 5,11,17,23-tetra-tert-butyl-25,27-bis(3-bromopropoxy)-26,28-dihydroxycalix[4]arene (2). The synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR spectral data, elemental analysis and ESI-MS.