37538-68-4

Basic information

• Product Name: Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione
• Synonyms: Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione;1H,2H,3H,4H-pyrido[3,2-d]pyriMidine-2,4-dione;2,4-Dihydroxypyrido[3,2-d]pyriMidine;1H,3H-Pyrido[3,2-d]pyriMidine-2,4-dione
• CAS NO: 37538-68-4
• Molecular Formula: C₇H₅N₃O₂
• Molecular Weight: 163.14
• Mol File: 37538-68-4.mol
• Article Data: 12

Chemical Properties

• Melting Point: 320 °C
• Appearance: /
• Density: 1.424g/cm³
• Refractive Index: 1.593
• PKA: 9.27±0.20(Predicted)
• CAS DataBase Reference: Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione(37538-68-4)
• EPA Substance Registry System: Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione(37538-68-4)

Safety Data

• Hazardous Substances Data: 37538-68-4(Hazardous Substances Data)

Usage

Uses

2,4-Dihydroxypyrido[3,2-d]pyrimidine is used as a reagent in the synthesis of diaminoquinazolines as antitubercular agents. 2,4-Dihydroxypyrido[3,2-d]pyrimidine may also be used as a potential histamine H4 receptor antagonist.

InChI:InChI=1/C7H5N3O2/c11-6-5-4(2-1-3-8-5)9-7(12)10-6/h1-3H,(H2,9,10,11,12)

Upstream product

• 1462-86-8 3-amino-pyridine-2-carboxylic acid 
• 57-13-6 urea 
• 590-28-3 potassium cyanate 
• 27507-08-0 3-(4-methoxybenzyl)pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione 
• 107468-48-4 2-carbamoyl-3-pyridylurea 
• 50608-99-6 3-amino-pyridine-2-carboxylic acid amide 
• 656801-64-8 methyl 3-isocyanatopyridine-2-carboxylate 
• 24195-07-1 pyridine-2,3-dicarboxylic acid 2-methyl ester 
• 699-98-9 Pyridine-2,3-dicarboxylic anhydride 
• 107468-47-3 N-(phenylsulphonyloxy)quinolinimide 

Downstream Products

• 24410-25-1 1,3-dimethylpyrido<3,2-d>pyrimidine 
• 39551-54-7 2,4-dichloropyrido[3,2-d]-pyrimidine 
• 915302-08-8 4-isopropylsulfanyl-2-phenylpyrido[3,2-d]pyrimidine 
• 915302-14-6 4-isopropylsulfanyl-2-(3-methoxyphenyl)pyrido[3,2-d]pyrimidine 
• 915302-21-5 2-chloropyrido[3,2-d]pyrimidine 

Relevant articles and documents

PYRIDOPYRIMIDINES AND METHODS OF THEIR USE

Disclosed are compounds useful in the treatment of neurological disorders. The compounds described herein, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological diseases.

Trisubstituted pyrido[2,3-D]pyrimidines, methods for preparing same and therapeutic uses thereof

The present invention relates to compounds of the following general formula (I): wherein: R1 is notably a group —NRaRb, Ra and Rb forming together with the nitrogen atom onto which they are bound, a h

2,4-quinazolinediamine derivatives, and preparation method and application thereof

The invention discloses 2,4-quinazolinediamine derivatives, and a preparation method and application thereof, belonging to the field of medicines and preparation and application thereof. The 2,4-quinazolinediamine derivatives comprises compounds as shown in a formula (I) which is described in the specification and a solvate, hydrate, tautomer and pharmaceutically acceptable salt thereof. Test results show that the 2,4-quinazolinediamine derivatives have strong Wolbachia resisting activity; and in the derivatives, 2-isopropylamido substitution has good effect, and compounds with better Wolbachia resisting activity can be obtained by changing a 4-amido group. The compounds have activity in resisting plasmodia, Wolbachia and bacteria.