37581-21-8

Basic information

• Product Name: Pyridine, 3-[(2-methylphenyl)methyl]-
• CAS NO: 37581-21-8
• Molecular Formula: C13H13N
• Molecular Weight: 183.253
• Mol File: 37581-21-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Pyridine, 3-[(2-methylphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-[(2-methylphenyl)methyl]-(37581-21-8)
• EPA Substance Registry System: Pyridine, 3-[(2-methylphenyl)methyl]-(37581-21-8)

Safety Data

• Hazardous Substances Data: 37581-21-8(Hazardous Substances Data)

Upstream product

• 29173-25-9 1,4-bis(trimethylsilyl)-1-aza-2,5-cyclohexadiene 
• 529-20-4 2-methylphenyl aldehyde 
• 110-86-1 pyridine 
• 626-60-8 3-Chloropyridine 
• 552-45-4 1-chloromethyl-2-methylbenzene 
• 626-55-1 3-Bromopyridine 

Relevant articles and documents

Synthesis of heteroaryl compounds through cross-coupling reaction of aryl bromides or benzyl halides with thienyl and pyridyl aluminum reagents

An efficient method for synthesis of useful biaryl building blocks containing 2-thienyl, 3-thienyl, 2-pyridyl, and 3-pyridyl moieties was provided through cross-coupling reactions of aryl bromides or benzyl halides with heteroaryl aluminum reagents in the presence of Pd(OAc)2 and (o-tolyl)3P. The coupling reaction also worked efficiently with heteroaryl bromides affording series of heterobiaryl compounds. The reaction of phenylbromide with in situ prepared 3-pyridyl aluminum was demonstrated to afford the product 8a in high yield. Additionally, the catalytic system was also suited well for the coupling reaction of benzyl halides with pyridyl aluminum reagents to afford series of pyridyl-arylmethane.

REGIOSELECTIVE ALKYL GROUP INTRODUCTION AT THE 3-POSITION OF PYRIDINE VIA 1,4-BIS(TRIMETHYLSILYL)-1,4-DIHYDROPYRIDINE

The reaction of 1,4-bis(trimethylsilyl)-1,4-dihydropyridine with aldehydes and ketones in the presence of tetrabutylammonium fluoride offers a convenient method for the preparation of 3-alkylpyridines.