37600-44-5

Basic information

• Product Name: Butanoic acid, 4-[(4-methylphenyl)amino]-4-oxo-
• Synonyms: Butanoic acid, 4-[(4-methylphenyl)amino]-4-oxo-;4-[(4-Methylphenyl)amino]-4-oxobutanoic acid;4'-Methylsuccinanilic acid;4-keto-4-[(4-methylphenyl)amino]butyric acid;ARONIS000501;CBKinase1_002429;CBKinase1_014829;EU-0003072
• CAS NO: 37600-44-5
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207
• Mol File: 37600-44-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 150℃
• Boiling Point: 457.3±28.0 °C(Predicted)
• Appearance: /
• Density: 1.245
• Storage Temp.: 2-8°C
• PKA: 4.72±0.10(Predicted)
• CAS DataBase Reference: Butanoic acid, 4-[(4-methylphenyl)amino]-4-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4-[(4-methylphenyl)amino]-4-oxo-(37600-44-5)
• EPA Substance Registry System: Butanoic acid, 4-[(4-methylphenyl)amino]-4-oxo-(37600-44-5)

Safety Data

• Hazardous Substances Data: 37600-44-5(Hazardous Substances Data)

Usage

General Description

Butanoic acid, 4-[(4-methylphenyl)amino]-4-oxo- is a chemical compound with a complex molecular structure containing a butanoic acid group and an amino group attached to a phenyl ring. It is also known as 4-methyl-N-(4-oxobutan-2-yl)aniline and is commonly used in the synthesis of pharmaceutical compounds and organic dyes. This chemical compound is commonly used in the pharmaceutical industry due to its potential application as a drug intermediate, and it also possesses a high potential for use as a dye intermediate due to its vibrant and stable color properties. However, it is important to note that this chemical compound needs to be handled with care and in compliance with safety regulations due to its potential hazards and risks.

Upstream product

• 328-50-7 α-ketoglutaric acid 
• 106-49-0 p-toluidine 
• 637-47-8 1,2-di(p-tolyl)hydrazine 
• 22264-20-6 3-(N,N'-Di-p-tolyl-hydrazinocarbonyl)-propionic acid methyl ester 
• 23344-25-4 N,N'-Di-(p-tolyl)-3-carboxypropionhydrazid 
• 2314-79-6 N-(p-tolyl)succinimide 
• 108-30-5 succinic acid anhydride 
• 67-66-3 chloroform 

Downstream Products

• 309733-25-3 1-[4-(bromomethyl)phenyl]pyrrolidine-2,5-dione 
• 356550-46-4 C₁₃H₁₇NO₃ 
• 135121-64-1 N-p-tolylsuccinisoimidium perchlorate 
• 86396-51-2 N-(4-methylphenyl)succinamide methyl ester 

Relevant articles and documents

Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway

Triple-negative breast cancer (TNBC) has an unfavorable prognosis attribute to its low differentiation, rapid proliferation and high distant metastasis rate. PI3K/Akt/mTOR as an intracellular signaling pathway plays a key role in the cell proliferation, m

Catalyst-Free Singlet Oxygen-Promoted Decarboxylative Amidation of α-Keto Acids with Free Amines

A novel catalyst-free decarboxylative amidation of α-keto acids with amines under mild conditions has been developed. Advantages of the new protocol include avoidance of metal catalysts and high levels of functional group tolerance. In addition, the reaction can be scaled up and shows high chemoselectivity. Preliminary mechanistic studies suggest that singlet oxygen, generated from oxygen under irradiation, is the key promoter for this catalyst-free transformation.

A facile and green synthesis of N-substituted imides

Anhydrides 1, 6 and 10 have been reacted, independently, with aromatic primary amines 2 in solid phase by simple physical grinding of reactants with p-toluenesulphonicacid as a catalyst to yield corresponding open chain derivatives, monoacid monoamides3,7 and 11 respectively. The latter have each been transformed into the corresponding cyclic derivatives, i.e. imides 5, 9 and 13 respectively in solid phase by simple physical grinding of each with K 2CO3, alkylating agent and tetrabutylammoniumbromide as a catalyst with short reaction times. These cyclic imides can also be obtained by physical grinding of each of 3, 7 and 11 with dicyclohexylcarbodimide as a dehydrating agent in solid phase.