376587-53-0

Basic information

• Product Name: 5-BROMO-3-METHYL-2-PYRIDINECARBALDEHYDE
• Synonyms: 5-BROMO-2-FORMYL-3-PICOLINE;5-BROMO-3-METHYL-2-PYRIDINECARBALDEHYDE;5-BROMO-3-METHYLPICOLINALDEHYDE;5-Bromo-3-methylpyridine-2-carboxaldehyde;5-Bromo-2-formyl-3-methylpyridine;5-Bromo-2-formyl-3-methylpyridine, 5-Bromo-3-methylpicolinaldehyde;5-Bromo-2-formyl-3-methylpyridine, >=97%
• CAS NO: 376587-53-0
• Molecular Formula: C7H6BrNO
• Molecular Weight: 200.03
• EINECS: 200-589-5
• Product Categories: Pyridine;pharmacetical;Building Blocks;Pyridine Series
• Mol File: 376587-53-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 260.929 °C at 760 mmHg
• Flash Point: 111.606 °C
• Appearance: /
• Density: 1.578 g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.86±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-3-METHYL-2-PYRIDINECARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-3-METHYL-2-PYRIDINECARBALDEHYDE(376587-53-0)
• EPA Substance Registry System: 5-BROMO-3-METHYL-2-PYRIDINECARBALDEHYDE(376587-53-0)

Safety Data

• Hazardous Substances Data: 376587-53-0(Hazardous Substances Data)

Usage

General Description

5-Bromo-3-methyl-2-pyridinecarbaldehyde, also known as 5-Bromo-3-methylpyridine-2-carboxaldehyde, is a chemical compound used mainly in the fields of chemistry and scientific research. It falls under the classification of heterocyclic compounds - more precisely, pyridines and derivatives. It appears as a pure, solid substance, typically crystalline or powder-like, with a molecular formula of C7H6BrNO. This chemical's specific properties, including its appearance, melting point, boiling point, or density, may vary depending on environmental factors and the specifics of its preparation. It is advised to handle and store it with care, considering potential safety hazards. Its exact usage can be diverse, contingent upon lab needs, but is primarily employed as a reactant or precursor in various organic synthesis reactions and chemical studies.

InChI:InChI=1/C7H6BrNO/c1-5-2-6(8)3-9-7(5)4-10/h2-4H,1H3

Upstream product

• 3430-18-0 2,5-dibromo-3-methylpyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 376587-52-9 5-bromo-2-iodo-3-methylpyridine 

Relevant articles and documents

Povarov reaction, scope and limitations: Preparation of diversely heterocyclic tetrahydro-1H-cyclopenta[c]quinolines

Parallel synthesis of diverse heterocyclic-tetrahydro-1H-cyclopenta[c]quinolines in excellent yields and high endo diastereoselectivity has been described hereia These compounds are highly functionalized natural product-like tricyclic systems, which may be useful as biologically relevant targets. Fine tuning of the reaction conditions need to be performed depending on the nature and molecular structure of the heterocyclic aromatic carbaldehyde, as well as the choice of the Lewis acid catalyst. Synthesis of the heterocyclic aromatic aldehyde precursors of the Povarov Reaction is also described.

SUBSTITUTED TRICYCLIC COMPOUNDS WITH ACTIVITY TOWARDS EP1 RECEPTORS

The present invention belongs to the field of EP1 receptor ligands. More specifically it refers to compounds of general formula (I) having great affinity and selectivity for the EP1 receptor. The invention also refers to the process for their preparation, to their use as medicament for the treatment and/or prophylaxis of diseases or disorders mediated by the EP1 receptor as well as to pharmaceutical compositions comprising them.

Synthesis of heteroarylamine intermediate compounds

Disclosed are novel 2-(5-halopyridyl) and 2-(5-halopyrimidinyl) magnesium halides, processes of making and their use in the efficient synthesis in their respective 5-halo-2-substituted pyridines and pyrimidines.