37663-44-8 Usage
Description
4-SPIRO-[1-PHTHALAN]PIPERIDINE HYDROCHLORIDE, also known as Spiro[isobenzofuran-1(3H),4'-piperidine], is a (spiro)(hetero)cyclic amide compound that serves as a modulator of 11-β hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme plays a crucial role in the regulation of glucocorticoid hormones, which are involved in various physiological processes, including glucose metabolism, inflammation, and immune response.
Uses
Used in Pharmaceutical Industry:
4-SPIRO-[1-PHTHALAN]PIPERIDINE HYDROCHLORIDE is used as a pharmaceutical agent for modulating the activity of 11-β hydroxysteroid dehydrogenase type 1 (11β-HSD1). By targeting this enzyme, it can potentially be employed in the treatment of various conditions related to glucocorticoid dysregulation, such as metabolic disorders, inflammatory diseases, and immune system disorders.
Used in Drug Development:
4-SPIRO-[1-PHTHALAN]PIPERIDINE HYDROCHLORIDE is used as a lead compound in drug development for the discovery of new therapeutic agents targeting 11β-HSD1. Its unique (spiro)(hetero)cyclic amide structure provides a foundation for further optimization and modification to improve its potency, selectivity, and pharmacokinetic properties, ultimately leading to the development of more effective drugs for treating related diseases.
Used in Research Applications:
4-SPIRO-[1-PHTHALAN]PIPERIDINE HYDROCHLORIDE is used as a research tool for studying the role of 11-β hydroxysteroid dehydrogenase type 1 in various biological processes. It can be employed in in vitro and in vivo experiments to investigate the enzyme's function, its interaction with other cellular components, and its potential as a therapeutic target for different diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 37663-44-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,7,6,6 and 3 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 37663-44:
(7*3)+(6*7)+(5*6)+(4*6)+(3*3)+(2*4)+(1*4)=138
138 % 10 = 8
So 37663-44-8 is a valid CAS Registry Number.
37663-44-8Relevant articles and documents
CYCLOALKANOPYRIDINE DERIVATIVE
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Page/Page column 49-50, (2010/11/24)
Provided are cycloalkanopyridine derivatives of formula [I]: [wherein the symbols are the same as those stated in the description]. The compounds act as a nociceptin receptor antagonist, and are useful as medicines for diseases associated with a nociceptin receptor, for example, as a reliever against tolerance to a narcotic analgesic; a reliever against dependence on or addiction to a narcotic analgesic; an analgesic enhancer; an antiobesitic or appetite suppressor; a treating or prophylactic agent for cognitive impairment and dementia/amnesia; an agent for treating developmental cognitive abnormality; a remedy for schizophrenia; an agent for treating neurodegenerative diseases; an anti-depressant or treating agent for affective disorder; a treating or prophylactic agent for diabetes insipidus; a treating or prophylactic agent for polyuria; or a remedy for hypotension.
