37663-46-0

Basic information

• Product Name: Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one
• Synonyms: Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one;3H-Spiro[2-benzofuran-1,4'-piperidine]-3-one;3-Oxospiro[isobenzofuran-1(3H),4'-piperidine];Spiro[phthalan-1,4'-piperidin]-3-one;3H-spiro[isobenzofuran-1,4'-piperidin]-3-one
• CAS NO: 37663-46-0
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.24
• Mol File: 37663-46-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 132-133 °C
• Boiling Point: 406.849 °C at 760 mmHg
• Flash Point: 199.855 °C
• Appearance: /
• Density: 1.25
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.98±0.20(Predicted)
• CAS DataBase Reference: Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one(37663-46-0)
• EPA Substance Registry System: Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one(37663-46-0)

Safety Data

• Hazardous Substances Data: 37663-46-0(Hazardous Substances Data)

Usage

Description

Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one is a complex organic compound that features a spiro linkage between an isobenzofuran and a piperidine ring. This unique structure endows it with specific chemical properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one is used as a key intermediate in the synthesis of cyclin-dependent kinase (CDK) inhibitors. These inhibitors are important for the development of drugs targeting various diseases, including cancer, by disrupting the cell cycle and preventing uncontrolled cell proliferation.
Used in Research and Development:
In the field of medicinal chemistry, Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one serves as a valuable building block for the design and synthesis of novel compounds with potential therapeutic applications. Its unique structure allows researchers to explore new avenues in drug discovery and development.
Used in Chemical Synthesis:
Spiro[isobenzofuran-1(3H),4'-piperidin]-3-one can be utilized in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its versatile structure makes it a useful component in the creation of new molecules with desired properties and functions.

Upstream product

• 32664-13-4 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 54595-99-2 1-benzyl-4-[2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-phenyl]-piperidin-4-ol 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 93-98-1 N-phenyl benzoyl amide 
• 37663-42-6 1'-benzylspiro[isobenzofuran-1(3H),4'-piperidine]-3-one 
• 54596-21-3 2-bromo-N-(2-hydroxy-1,1-dimethylethyl)benzamide 

Downstream Products

• 1175705-83-5 C₂₂H₁₉N₃O₃S 
• 1175705-80-2 C₂₂H₂₀N₄O₃ 
• 1175705-78-8 C₂₂H₂₀N₄O₃ 
• 1175706-27-0 C₂₂H₁₈ClN₃O₄ 
• 1175706-26-9 C₂₂H₁₈ClN₃O₄ 
• 1175706-24-7 C₂₂H₁₈ClN₃O₄ 
• 1175706-20-3 C₂₄H₁₉F₃N₄O₃ 
• 1175706-18-9 C₂₄H₁₉F₃N₄O₃ 
• 1175706-16-7 C₂₃H₁₉FN₄O₃ 
• 1175706-13-4 C₂₃H₁₉FN₄O₃ 
• 1175706-11-2 C₂₄H₂₂N₄O₄ 
• 1175706-10-1 C₂₄H₂₂N₄O₄ 
• 1175706-07-6 C₂₄H₂₂N₄O₄ 
• 1175706-05-4 C₂₃H₁₉ClN₄O₃ 

Relevant articles and documents

INDOL-3-YL-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS

The invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the spiro-piperidine head group A and the residues R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, methods for preparing the compounds and pharmaceutical compositions, and their use in the treatment of dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders.

Spiro piperidines. I. Synthesis of spiro[isobenzofuran 1(3 H),4' piperidines] and spiro[isobenzofuran 1(3 H),3' piperidines]

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