37721-75-8

Basic information

• Product Name: 2,3,5,6-TETRABROMO-4-METHYLPHENOL
• Synonyms: 2,3,5,6-TETRABROMO-4-METHYLPHENOL;2,3,5,6-TETRABROMO-P-CRESOL;Tetrabromo-p-cresol;4-methyl-2.3.5.6-tetrabromophenol ;2,3,5,6-TETRABROMO-P-CRESOL 95+%;2,3,5,6-TETRABROMO-4-METHYLPHENOL 98%;2,3,5,6-Tetrabromo-4-methylphenol,98%;2,3,5,6-Tetrabromo-4-cresol
• CAS NO: 37721-75-8
• Molecular Formula: C₇H₄Br₄O
• Molecular Weight: 423.72
• Mol File: 37721-75-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 195-200 °C
• Boiling Point: 340°C (rough estimate)
• Flash Point: 151.8 °C
• Appearance: /
• Density: 2.4745 (rough estimate)
• Vapor Pressure: 0.000106mmHg at 25°C
• Refractive Index: 1.5000 (estimate)
• Storage Temp.: 2-8°C
• Solubility: very faint turbidity in hot Methanol
• CAS DataBase Reference: 2,3,5,6-TETRABROMO-4-METHYLPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5,6-TETRABROMO-4-METHYLPHENOL(37721-75-8)
• EPA Substance Registry System: 2,3,5,6-TETRABROMO-4-METHYLPHENOL(37721-75-8)

Safety Data

• Hazard Codes: Xi,C
• Statements: 36/37/38
• Safety Statements: 24/25
• HazardClass: IRRITANT, IRRITANT-HARMFUL, CORR
• Hazardous Substances Data: 37721-75-8(Hazardous Substances Data)

Usage

Chemical Properties

OFF-WHITE TO BEIGE-BROWN CRYSTALLINE NEEDLES

InChI:InChI=1/C7H4Br4O/c1-2-3(8)5(10)7(12)6(11)4(2)9/h12H,1H3

Upstream product

• 104-93-8 p-methylanizole 
• 106-44-5 p-cresol 
• 622-60-6 1-ethoxy-4-methylbenzene 
• 13979-81-2 3,5-dibromo-4-methylphenol 
• 36776-51-9 2,3,6-tribromo-4-methyl-phenol 
• 90-15-3 α-naphthol 
• 95111-49-2 4-nitro-4-methyl-2,3,5,6-tetrabromo-2,5-cyclohexadien-1-one 
• 3588-80-5 5-methoxynaphthalen-1-ol 
• 150-76-5 4-methoxy-phenol 
• 7726-95-6 bromine 
• 7727-15-3 aluminium bromide 
• 60-29-7 diethyl ether 
• 67-66-3 chloroform 
• 64-19-7 acetic acid 

Downstream Products

• 102703-94-6 meso-2,5-bis-(2,3,5,6-tetrabromo-4-methyl-phenoxy)-adipic acid dimethyl ester 
• 102703-94-6 racem.-2,5-bis-(2,3,5,6-tetrabromo-4-methyl-phenoxy)-adipic acid dimethyl ester 
• 608-71-9 Pentabromophenol 
• 13979-81-2 3,5-dibromo-4-methylphenol 
• 381670-44-6 1,2,4,5-tetrabromo-6-hexyloxy-3-methylbenzene 
• 5435-58-5 pentabromophenyl acetate 
• 94400-20-1 4-nitro-4-methyl-2,3,5,6-tetrachloro-2,5-cyclohexadien-1-one 
• 89583-86-8 2,3,5,6-tetrabromo-4-hydroxybenzenemethanol 
• 381670-46-8 6-(2-ethylhexyloxy)-3-methylbenzene-1,2,4-tricarbonitrile 
• 381670-38-8 6-hexyloxy-3-methylbenzene-1,2,4-tricarbonitrile 
• 59410-14-9 2,3,5,6-tetrabromo-4-methyoxytoluene 
• 139558-66-0 4-methyl-4-nitro<15N>-2,3,5,6-tetrabromocyclohexa-2,5-dienone 
• 77339-25-4 2,3,4,5,6-pentabromo-4-methylcyclohexa-2,5-dienone 
• 95111-50-5 2,3,5,6-tetrabromo-4-hydroxy-4-methylcyclohexa-2,5-dienone 

Relevant articles and documents

Facile synthesis of 2,3,5,6-tetrabromo-4-methyl-nitrocyclohexa-2,5-dien-1- one, a mild nitration reagent

Nitrocylcohexadienones have been applied as nitration reagents for mild, mono-nitrating reactions. The original synthesis of 2,3,5,6-tetrabromo-4-methyl- 4-nitrocylcohexa-2,5-dien-1-one appeared to be difficult to pursue due to both the solvent system and

POLYBROMINATED AROMATIC COMPOUNDS V. REACTION OF PENTABROMOTOLUENE WITH SODIUM METHOXIDE IN PYRIDINE

During the reaction of pentabromotoluene with sodium methoxide in pyridine, together with the products from methoxydebromination and protodebromination, the products from substitution of both the bromine atom in the aromatic ring and hydrogen atom in the methyl group by methoxy groups are formed.The directing effect of the methyl and methoxymethyl groups during substitution of the bromine in the pentabromophenyl ring by the methoxide ion was studied, and it was shown that the directing selectivity of these substituents is low.The methyl group is predominantly a meta-orientant, whereas the methoxymethyl group is predominantly a para-orientant.

Nitrocyclohexadienones : a new class of nitrating agents

Various nitrocyclohexadienones are proposed as new nitrating agents. These compounds are easy to prepare from corresponding phenols, easy to handle and stable. Nitrocyclohexadienones act as nitronium carriers using rearomatization as the driving force and permit nitration of highly activated substrates under mild conditions and with good yields.