37772-93-3

Basic information

• Product Name: 5-Methylpyrrolidine-2,4-dione
• Synonyms: 5-Methylpyrrolidine-2,4-dione;(±)-5-Methyl-2,4-pyrrolidinedione;2,4-Pyrrolidinedione, 5-methyl-
• CAS NO: 37772-93-3
• Molecular Formula: C5H7NO2
• Molecular Weight: 113.11458
• EINECS: 1533716-785-6
• Mol File: 37772-93-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 338.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.157±0.06 g/cm3(Predicted)
• PKA: 12.83±0.40(Predicted)
• CAS DataBase Reference: 5-Methylpyrrolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methylpyrrolidine-2,4-dione(37772-93-3)
• EPA Substance Registry System: 5-Methylpyrrolidine-2,4-dione(37772-93-3)

Safety Data

• Hazardous Substances Data: 37772-93-3(Hazardous Substances Data)

Usage

General Description

5-Methylpyrrolidine-2,4-dione, also known as N-Methylglutaramic acid, is a chemical compound with the molecular formula C6H9NO3. It is a cyclic imide and a derivative of glutarimide. 5-Methylpyrrolidine-2,4-dione is often used as a building block in organic synthesis, particularly in the production of pharmaceuticals and other biologically active molecules. 5-Methylpyrrolidine-2,4-dione has a variety of potential applications in the pharmaceutical and agricultural sectors due to its ability to act as a precursor in the synthesis of various organic compounds. This chemical is available for purchase from various chemical suppliers and can be used in research and industrial applications.

Upstream product

• 89776-89-6 methyl 4-hydroxy-5-methyl-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate 

Relevant articles and documents

Studies on the synthesis and bioactivities of 4-amino derivatives of tetramic acid

In order to study the potential bioactivities of 4-amino tetramic acid derivatives, the 4-amination products of pyrrolidine-2,4-diones (5) and 4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrole-3-carboxylates (4) were prepared. The 4-amination of 5 took place in high yield when catalyzed by acetic acid, whereas the 4-amination of 4 was achieved through a 4-ethoxy intermediate, which was prepared by acidic etherification. Their herbicidal, fungicidal, insecticidal, and antitumor activities were tested. The bioassays showed that two of the compounds exhibited good herbicidal activity against dicot Arabidopsis thaliana at a concentration of 10 μg/mL, and one compound gave instinct fungicidal activity against Pythium sp. at a concentration of 2 μg/mL.