377767-11-8

Basic information

• Product Name: C₁₁H₈ClFN₂O
• Synonyms: C₁₁H₈ClFN₂O
• CAS NO: 377767-11-8
• Molecular Weight: 238.649
• Mol File: 377767-11-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₁₁H₈ClFN₂O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₈ClFN₂O(377767-11-8)
• EPA Substance Registry System: C₁₁H₈ClFN₂O(377767-11-8)

Safety Data

• Hazardous Substances Data: 377767-11-8(Hazardous Substances Data)

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 100553-83-1 2-(4-fluorophenyl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one 
• 371-14-2 4-fluorophenylhydrazine 

Downstream Products

• 926190-52-5 C₁₁H₈ClFN₂O₂ 
• 1343477-90-6 C₂₀H₁₆ClFN₄O 
• 1343477-92-8 C₁₉H₁₅ClFN₃O 
• 1343477-95-1 C₂₀H₁₆ClFN₄S 
• 732269-37-3 C₂₂H₁₆FN₅ 

Relevant articles and documents

Discovery of novel triazole-containing pyrazole ester derivatives as potential antibacterial agents

To develop new antibacterial agents, a series of novel triazole-containing pyrazole ester derivatives were designed and synthesized and their biological activities were evaluated as potential topoisomerase II inhibitors. Compound 4d exhibited the most potent antibacterial activity with Minimum inhibitory concentration (MIC) alues of 4 μg/mL, 2 μg/mL, 4 μg/mL, and 0.5 μg/mL against Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, and Salmonella gallinarum, respectively. The in vivo enzyme inhibition assay 4d displayed the most potent topoisomerase II (IC50 = 13.5 μg/mL) and topoisomerase IV (IC50 = 24.2 μg/mL) inhibitory activity. Molecular docking was performed to position compound 4d into the topoisomerase II active site to determine the probable binding conformation. In summary, compound 4d may serve as potential topoisomerase II inhibitor.

Discovery of novel double pyrazole Schiff base derivatives as anti-tobacco mosaic virus (TMV) agents

Many pyrazole derivatives were reported to exhibit highly activity towards tobacco mosaic virus (TMV). In this work, an optimized pyrazole Schiff base scaffold was designed and introduced to derive novel potential TMV inhibitors. Thirty-six compounds were synthesized, characterized by elemental analysis, mass spectra and nuclear magnetic resonance (NMR) spectroscopy and evaluated by biological experiments. The bioassay results showed that some of the synthesized compounds exhibited excellent anti-TMV activities. Especially, 5-chloro-3-methyl-1H-pyrazole contained compound 4j showed ningnanmycin comparable inhibitory activity and can be considered as potential anti-TMV candidate agent. With molecular docking, compound 4j insert into nucleotide sequence (GAAGUU) of OriRNA stably which revealed nucleotide could be a target of these compounds.