3780-72-1

Basic information

• Product Name: Morsuximide
• Synonyms: Morsuximide;morfolep;2-Methyl-N-(morpholinomethyl)-2-phenylsuccinimide;3-Methyl-1-[(4-morpholinyl)methyl]-3-phenyl-2,5-pyrrolidinedione;Morpholep;S-210;3-methyl-1-(morpholin-4-ylmethyl)-3-phenyl-pyrrolidine-2,5-dione;3-methyl-1-(morpholin-4-ylmethyl)-3-phenylpyrrolidine-2,5-dione
• CAS NO: 3780-72-1
• Molecular Formula: C₁₆H₂₀N₂O₃
• Molecular Weight: 288.345
• Mol File: 3780-72-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 473°Cat760mmHg
• Flash Point: 239.9°C
• Appearance: /
• Density: 1.213g/cm³
• Vapor Pressure: 4.07E-09mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: Morsuximide(CAS DataBase Reference)
• NIST Chemistry Reference: Morsuximide(3780-72-1)
• EPA Substance Registry System: Morsuximide(3780-72-1)

Safety Data

• Hazardous Substances Data: 3780-72-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H20N2O3/c1-16(13-5-3-2-4-6-13)11-14(19)18(15(16)20)12-17-7-9-21-10-8-17/h2-6H,7-12H2,1H3

Upstream product

• 14231-67-5 (+/-)-2-Methyl-2-phenylbutanedioic acid 
• 110-91-8 morpholine 
• 50-00-0 formaldehyd 
• 1497-17-2 3-methyl-3-phenyl-pyrrolidine-2,5-dione 

Relevant articles and documents

Synthesis and anticonvulsant properties of new mannich bases derived from 3,3-disubstituted pyrrolidine-2,5-diones. Part IV

A library of 21 new N-Mannich bases of 3,3-diphenyl- (5a-g), 3-methyl-3-phenyl- (6a-g), and 3-ethyl-3-methylpyrrolidine-2,5-diones (7a-g) were synthesized and evaluated for their anticonvulsant activity in the maximum electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) seizure tests after intraperitoneal injection into mice. The acute neurological toxicity was determined applying the rotarod screen. The results in mice showed that 13 compounds were effective in the MES or/and scPTZ screen. From these, seven molecules were tested in the MES seizures after oral administration in rats. The quantitative studies showed that N-[{4-(2-hydroxyethyl)-piperazin-1-yl}-methyl] -3-methyl-3-phenylpyrrolidine-2,5-dione (6c) and N-[(4-benzylpiperidin-1-yl)- methyl]-3-methyl-3-phenylpyrrolidine-2,5-dione (6f) revealed higher protection in the MES and scPTZ tests than valproic acid or ethosuximide which were used as reference antiepileptic drugs. Four compounds (5c, 6c, 6e, 6f) showed high effectiveness in the 6-Hz psychomotor seizure model of partial and therapy resistant epilepsy.