37967-82-1Relevant articles and documents
Modular synthesis of 3,6-disubstituted-1,2,4-triazines via the cyclodehydration of β-keto- N -acylsulfonamides with hydrazine salts
Dowling, Matthew S.,Jiao, Wenhua,Hou, Jie,Jiang, Yuchun,Gong, Shangsheng
, p. 4229 - 4238 (2018)
A straightforward method for preparing 3,6-disubstituted-1,2,4-triazines through a redox-efficient cyclodehydration of β-keto-N-acylsulfonamides with hydrazine salts is described. Two approaches for synthesizing the requisite β-keto-N-acylsulfonamides are presented, which allow for the late stage incorporation of either the C3 or C6 substituent in a flexible manner from acid chlorides or α-bromoketones, respectively. The scope of this methodology includes primary and secondary sp3-linked substituents at both the C3 and C6 positions, and the mild reaction conditions tolerate a variety of sensitive functionalities.
STUDIES ON AS-TRIAZINE DERIVATIVES. IX. SYNTHESIS OF 5-SUBSTITUTED 1,2,4-TRIAZINE DERIVATIVES THROUGH AN ADDITION REACTION AND SUBSEQUENT OXIDATION
Konno, Shoetsu,Ohba, Setsuya,Sagi, Mataichi,Yamanaka, Hiroshi
, p. 1378 - 1382 (2007/10/02)
The addition reactions of various nucleophiles to 6-methyl-3-phenyl-1,2,4-triazine (1) were investigated and a practical preparation of 1 was developed.The reactions showed many similarities to those of quinazoline (at the 4-position) and acridine (at the